Central Nervous System Fungal Diseases in Children with Malignancies: A 15-Year Study from the Infection Working Group of The Hellenic Society of Pediatric Hematology Oncology

How to cite: Petrikkos, L.; Kourti, M.; Antoniadi, K.; Tziola, T.-S.; Sfetsiori, A.-E.; Antari, V.; Savoukidou, S.; Avgerinou, G.; Fillipidou, M.; Papakonstantinou, E.; Polychronopoulou, S.; Hatzipantelis, E.; Doganis, D.; Kattamis, A.; Papadakis, V.; Roilides, E.; Tragiannidis, A. Central Nervous System Fungal Diseases in Children with Malignancies: A 15-Year Study from the Infection Working Group of The Hellenic Society of Pediatric Hematology Oncology. Preprints 2024, 2024080531. https://doi.org/10.20944/preprints202408.0531.v1 Petrikkos, L.; Kourti, M.; Antoniadi, K.; Tziola, T.-S.; Sfetsiori, A.-E.; Antari, V.; Savoukidou, S.; Avgerinou, G.; Fillipidou, M.; Papakonstantinou, E.; Polychronopoulou, S.; Hatzipantelis, E.; Doganis, D.; Kattamis, A.; Papadakis, V.; Roilides, E.; Tragiannidis, A. Central Nervous System Fungal Diseases in Children with Malignancies: A 15-Year Study from the Infection Working Group of The Hellenic Society of Pediatric Hematology Oncology. Preprints 2024, 2024080531. https://doi.org/10.20944/preprints202408.0531.v1

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MDPI and ACS Style

Petrikkos, L.; Kourti, M.; Antoniadi, K.; Tziola, T.-S.; Sfetsiori, A.-E.; Antari, V.; Savoukidou, S.; Avgerinou, G.; Fillipidou, M.; Papakonstantinou, E.; Polychronopoulou, S.; Hatzipantelis, E.; Doganis, D.; Kattamis, A.; Papadakis, V.; Roilides, E.; Tragiannidis, A. Central Nervous System Fungal Diseases in Children with Malignancies: A 15-Year Study from the Infection Working Group of The Hellenic Society of Pediatric Hematology Oncology. Preprints 2024, 2024080531. https://doi.org/10.20944/preprints202408.0531.v1

APA Style

Petrikkos, L., Kourti, M., Antoniadi, K., Tziola, T. S., Sfetsiori, A. E., Antari, V., Savoukidou, S., Avgerinou, G., Fillipidou, M., Papakonstantinou, E., Polychronopoulou, S., Hatzipantelis, E., Doganis, D., Kattamis, A., Papadakis, V., Roilides, E., & Tragiannidis, A. (2024). Central Nervous System Fungal Diseases in Children with Malignancies: A 15-Year Study from the Infection Working Group of The Hellenic Society of Pediatric Hematology Oncology. Preprints. https://doi.org/10.20944/preprints202408.0531.v1

Chicago/Turabian Style

Petrikkos, L., Emmanuel Roilides and Athanassios Tragiannidis. 2024 "Central Nervous System Fungal Diseases in Children with Malignancies: A 15-Year Study from the Infection Working Group of The Hellenic Society of Pediatric Hematology Oncology" Preprints. https://doi.org/10.20944/preprints202408.0531.v1

Abstract

We analyzed data of pediatric invasive fungal diseases of the central nervous system (CNS-IFDs) reported by five of total eight Pediatric Hematology-Oncology Departments in Greece for 15 years (2007-2022). A total of twelve patients (11 boys, median age: 9.5yrs range: 2-16) were reported suffering from CNS-IFDs. Underlying malignancy was acute lymphoblastic leukemia in 9/12, and acute myeloid leukemia, Ewing sarcoma and rhabdomyosarcoma in one each. Eleven patients presented with CNS-related symptoms (i.e seizures, headache, cerebral palsy, ataxia, hallucination, seizures, blurred vision, amaurosis). All patients had pathological MRI findings. Multifocal fungal disease was observed in 6/12 patients. Nine proven and three probable CNS-IFD cases were diagnosed. Causative pathogens in proven cases were Aspergillus spp. and Candida albicans (n=2 each), Mucor spp., Rhizopus arrhizus, Absidia spp., Fusarium oxysporum and Cryptococcus neoformans (n=1 each). Causative pathogens in probable cases were Aspergillus spp. (n=2) and Candida spp. (n=1). All patients received appropriate antifungal therapy (median duration: 69.5 days, range 19-364). Two patients underwent additional surgical treatment. Six patients admitted to ICU due to complications. Three patients (25%) died, two due to IFD and one due to underlying disease. Early recognition and prompt intervention of CNS-IFDs may rescue the patients and improve overall survival.

Keywords

central nervous system; invasive fungal infection; children; malignancies; outcome; brain abscess

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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