Version 1
: Received: 6 August 2024 / Approved: 7 August 2024 / Online: 8 August 2024 (12:14:52 CEST)
How to cite:
MAHAPATRA, C.; Thakkar, R.; Kumar, R. Modulatory Impact of Oxidative Stress on Membrane Action Potentials in Pathophysiological States: A Comprehensive Review. Preprints2024, 2024080562. https://doi.org/10.20944/preprints202408.0562.v1
MAHAPATRA, C.; Thakkar, R.; Kumar, R. Modulatory Impact of Oxidative Stress on Membrane Action Potentials in Pathophysiological States: A Comprehensive Review. Preprints 2024, 2024080562. https://doi.org/10.20944/preprints202408.0562.v1
MAHAPATRA, C.; Thakkar, R.; Kumar, R. Modulatory Impact of Oxidative Stress on Membrane Action Potentials in Pathophysiological States: A Comprehensive Review. Preprints2024, 2024080562. https://doi.org/10.20944/preprints202408.0562.v1
APA Style
MAHAPATRA, C., Thakkar, R., & Kumar, R. (2024). Modulatory Impact of Oxidative Stress on Membrane Action Potentials in Pathophysiological States: A Comprehensive Review. Preprints. https://doi.org/10.20944/preprints202408.0562.v1
Chicago/Turabian Style
MAHAPATRA, C., Ravindra Thakkar and Ravinder Kumar. 2024 "Modulatory Impact of Oxidative Stress on Membrane Action Potentials in Pathophysiological States: A Comprehensive Review" Preprints. https://doi.org/10.20944/preprints202408.0562.v1
Abstract
Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defenses, significantly affects cellular function and viability. It plays a pivotal role in modulating action potentials (APs), essential for properly functioning excitable cells such as neurons, smooth muscles, pancreatic beta cells, and myocytes. The interaction between oxidative stress and AP dynamics is crucial for understanding the pathophysiology of various conditions, including neurodegenerative diseases, cardiac arrhythmias, and ischemia-reperfusion injuries. This review explores how oxidative stress influences APs, focusing on alterations in ion channel functionality, signaling pathways, and membrane properties. By integrating current research, we aim to elucidate how oxidative stress contributes to disease progression and discuss potential therapeutic interventions targeting this interaction.
Keywords
Oxidative stress; action potential; biophysics; ion channel; pathophysiology
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
