Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients

Sean McCallion; Thomas McLarnon; Eamonn Cooper; Andrew English; Steven Watterson; Melody Chemaly; Cathy M. McGeough; Amanda Eakin; Tan Ahmed; Philip Gardiner; Adrian Pendleton; Gary Wright; Declan McGuigan; Maurice O'Kane; Aaron Peace; Ying Kuan; David S. Gibson; Paula L. McClean; Catriona Kelly; Victoria E. McGilligan; Elaine K. Murray; Frank McCarroll; Anthony J. Bjourson; Taranjit Singh Rai

doi:10.20944/preprints202408.0594.v1

Preprint Article Version 1 This version is not peer-reviewed

Version 1 : Received: 7 August 2024 / Approved: 8 August 2024 / Online: 8 August 2024 (08:48:50 CEST)

Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage or metabolic insult. Senescence is associated with aging and chronic age associated diseases such as cardiovascular disease and diabetes. The involvement of cellular senescence in Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) is not fully understood however, recent studies suggest that such patients have a higher-than-normal level of cellular senescence and accelerated aging. This study aimed to discover key biomarkers of senescence in AKI and CKD patients compared to other chronic ageing diseases as controls. We show that senescence proteins CKAP4 and PTX3 are upregulated in AKI and CKD patients compared with controls with chronic diseases suggesting they may play in a role in overall kidney disease development. Additionally, CKAP4 was found to be differentially expressed in both AKI and CKD when compared to unhealthy controls hence this biomarker could be prognostic senescence biomarker of both AKI and CKD.

Senescence; chronic kidney disease; acute kidney injury; biomarker; machine learning

Biology and Life Sciences, Aging

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Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients

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