Preprint Review Version 1 This version is not peer-reviewed

Genotype-Phenotype Correlations in Inherited Cardiomyopathies, Their Role in Clinical Decision-Making and Implications in Personalized Cardiac Medicine in Multi-omics as Well as Disease Modelling Eras

Yaqob Samir Taleb
* ,
Paras Memon
,
Aftab Ahmed Jalbani
,
Nouf AlMutairi
,
Sarah Al Mukhaylid
,
Nawaf Alanazi
,
Abdulkareem Al-Garni
,
Muneera Altaweel
,
Muhammad Aamir Khan
,
Muhammad Farooq Sabar
,
Zafar Iqbal
*
Version 1 : Received: 8 August 2024 / Approved: 9 August 2024 / Online: 9 August 2024 (12:13:29 CEST)

How to cite: Taleb, Y. S.; Memon, P.; Jalbani, A. A.; AlMutairi, N.; Al Mukhaylid, S.; Alanazi, N.; Al-Garni, A.; Altaweel, M.; Aamir Khan, M.; Farooq Sabar, M.; Iqbal, Z. Genotype-Phenotype Correlations in Inherited Cardiomyopathies, Their Role in Clinical Decision-Making and Implications in Personalized Cardiac Medicine in Multi-omics as Well as Disease Modelling Eras. Preprints 2024, 2024080682. https://doi.org/10.20944/preprints202408.0682.v1 Taleb, Y. S.; Memon, P.; Jalbani, A. A.; AlMutairi, N.; Al Mukhaylid, S.; Alanazi, N.; Al-Garni, A.; Altaweel, M.; Aamir Khan, M.; Farooq Sabar, M.; Iqbal, Z. Genotype-Phenotype Correlations in Inherited Cardiomyopathies, Their Role in Clinical Decision-Making and Implications in Personalized Cardiac Medicine in Multi-omics as Well as Disease Modelling Eras. Preprints 2024, 2024080682. https://doi.org/10.20944/preprints202408.0682.v1

Abstract

Inherited cardiomyopathies are a diverse group of heart muscle diseases caused by genetic mutations that result in structural and functional abnormalities of the myocardium. Understanding genotype-phenotype correlations in these conditions is vital for personalized cardiac medicine, enabling targeted therapeutic strategies and predictive diagnostics. This review explores the major types of inherited cardiomyopathies—hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and restrictive cardiomyopathy (RCM)—and provides detailed insights into how different genetic mutations manifest as clinical features. The integration of multi-omics approaches and advanced disease modeling techniques has enhanced our ability to dissect these correlations. The review also discusses the implications of these findings for personalized medicine, including tailored therapeutic strategies, predictive diagnostics, and future research directions.

Keywords

Cardiomyopathy; Multi-omics techniques; personalized medicine; genetic testing

Subject

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.