Version 1
: Received: 11 August 2024 / Approved: 12 August 2024 / Online: 12 August 2024 (13:43:57 CEST)
How to cite:
Mann, G. S.; Khan, S. W.; Movva, T.; Malik, A.; Ahmadi, L.; Allam, M. P.; Panjiyar, B. Comparing the Impact of Low Frequency vs High Frequency Deep Brain Stimulation in Patients with Parkinson’s Disease: A Systematic Review. Preprints2024, 2024080819. https://doi.org/10.20944/preprints202408.0819.v1
Mann, G. S.; Khan, S. W.; Movva, T.; Malik, A.; Ahmadi, L.; Allam, M. P.; Panjiyar, B. Comparing the Impact of Low Frequency vs High Frequency Deep Brain Stimulation in Patients with Parkinson’s Disease: A Systematic Review. Preprints 2024, 2024080819. https://doi.org/10.20944/preprints202408.0819.v1
Mann, G. S.; Khan, S. W.; Movva, T.; Malik, A.; Ahmadi, L.; Allam, M. P.; Panjiyar, B. Comparing the Impact of Low Frequency vs High Frequency Deep Brain Stimulation in Patients with Parkinson’s Disease: A Systematic Review. Preprints2024, 2024080819. https://doi.org/10.20944/preprints202408.0819.v1
APA Style
Mann, G. S., Khan, S. W., Movva, T., Malik, A., Ahmadi, L., Allam, M. P., & Panjiyar, B. (2024). <strong></strong>Comparing the Impact of Low Frequency vs High Frequency Deep Brain Stimulation in Patients with Parkinson’s Disease: A Systematic Review. Preprints. https://doi.org/10.20944/preprints202408.0819.v1
Chicago/Turabian Style
Mann, G. S., MD Parbej Allam and Binay Panjiyar. 2024 "<strong></strong>Comparing the Impact of Low Frequency vs High Frequency Deep Brain Stimulation in Patients with Parkinson’s Disease: A Systematic Review" Preprints. https://doi.org/10.20944/preprints202408.0819.v1
Abstract
Aim: Deep brain stimulation (DBS) involves implanting electrodes in specific brain areas. High-frequency Stimulation (HFS) and low-frequency Stimulation (LFS) target motor and non-motor symptoms differently. DBS is crucial in Parkinson's disease treatment for managing medication-resistant symptoms and improving quality of life. This review aims to evaluate the differential impact of high-frequency and low-frequency deep brain stimulation (DBS) on motor symptoms in Parkinson's disease (PD) patients. This systematic review adheres to PRISMA guidelines and focuses on clinical studies involving human subjects. Methods: Systematic search in electronic databases (PubMed, Google Scholar, Science Direct, Cochrane Collaboration Database of Randomized Trials) was performed to identify randomized controlled trials (RCTs) up to 13th July 2024. Results: Among 126 pooled patients from 8 RCTs, it was found that LFS significantly improved gait stability, swallowing, and verbal fluency with minimal adverse effects. Conversely, HFS was effective in reducing rigidity and tremor but was associated with potential side effects such as gait and speech impairment. Conclusion: The review highlights the nuanced effects of STN-DBS frequencies in Parkinson's treatment, suggesting high-frequency improves rigidity and tremor but may cause side effects, while low-frequency enhances gait stability and speech, necessitating further research for optimized, patient-specific therapies.
Keywords
Parkinson’s disease; deep brain stimulation; neurology; neuro-degenerative diseases
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
