Version 1
: Received: 12 August 2024 / Approved: 12 August 2024 / Online: 12 August 2024 (14:49:29 CEST)
How to cite:
Veremeyko, T.; Barteneva, N.; Vorobyev, I.; Ponomarev, E. D. The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought. Preprints2024, 2024080831. https://doi.org/10.20944/preprints202408.0831.v1
Veremeyko, T.; Barteneva, N.; Vorobyev, I.; Ponomarev, E. D. The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought. Preprints 2024, 2024080831. https://doi.org/10.20944/preprints202408.0831.v1
Veremeyko, T.; Barteneva, N.; Vorobyev, I.; Ponomarev, E. D. The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought. Preprints2024, 2024080831. https://doi.org/10.20944/preprints202408.0831.v1
APA Style
Veremeyko, T., Barteneva, N., Vorobyev, I., & Ponomarev, E. D. (2024). The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought. Preprints. https://doi.org/10.20944/preprints202408.0831.v1
Chicago/Turabian Style
Veremeyko, T., Ivan Vorobyev and Eugene D. Ponomarev. 2024 "The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought" Preprints. https://doi.org/10.20944/preprints202408.0831.v1
Abstract
Neurologic disorders such as traumatic brain injury, multiple sclerosis, Alzheimer’s disease, and drug-resistant epilepsy have a high socioeconomic impact around the world. Current therapies for these disorders are often not effective. This creates a demand for the development of new therapeutic approaches to treat these disorders. Recent data suggest that autoreactive naturally occurring immunoglobulins produced by subsets of B cells called B1 B cells combined with complement are actively involved in the processes of restoration of neuronal functions during pathological conditions and remyelination. The focus of this review is to discuss the possibility of creating specific therapeutic antibodies that can activate and fix complement to enhance neuronal survival and promote central nervous system repair after injuries associated with many types of neurodegenerative diseases.
Keywords
central nervous system (CNS); neurodegeneration; CNS repair; complement; immediate early genes (IEGs); immunoglobulins; natural autoantibodies (NAAs); B1 B cells
Subject
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
