PreprintReviewVersion 1This version is not peer-reviewed
The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics and Review of the Literature
Version 1
: Received: 9 August 2024 / Approved: 12 August 2024 / Online: 13 August 2024 (07:45:45 CEST)
How to cite:
Harris, P.; Farberg, A.; Hopkins, J.; Ma, L.; Serure, D.; Robbins, B.; Osborne, C.; Bravo, L.; Lausser, P.; Boatner, A. The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics and Review of the Literature. Preprints2024, 2024080846. https://doi.org/10.20944/preprints202408.0846.v1
Harris, P.; Farberg, A.; Hopkins, J.; Ma, L.; Serure, D.; Robbins, B.; Osborne, C.; Bravo, L.; Lausser, P.; Boatner, A. The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics and Review of the Literature. Preprints 2024, 2024080846. https://doi.org/10.20944/preprints202408.0846.v1
Harris, P.; Farberg, A.; Hopkins, J.; Ma, L.; Serure, D.; Robbins, B.; Osborne, C.; Bravo, L.; Lausser, P.; Boatner, A. The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics and Review of the Literature. Preprints2024, 2024080846. https://doi.org/10.20944/preprints202408.0846.v1
APA Style
Harris, P., Farberg, A., Hopkins, J., Ma, L., Serure, D., Robbins, B., Osborne, C., Bravo, L., Lausser, P., & Boatner, A. (2024). The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics and Review of the Literature. Preprints. https://doi.org/10.20944/preprints202408.0846.v1
Chicago/Turabian Style
Harris, P., Pauline Lausser and Amanda Boatner. 2024 "The State of the Art of Image Guided Superficial Radiation Therapy Treatment of Non-melanoma Skin Cancer in Outpatient Dermatology Clinics and Review of the Literature" Preprints. https://doi.org/10.20944/preprints202408.0846.v1
Abstract
Introduction Image Guided Superficial Radiation Therapy (IGSRT) is a novel technology which combines traditional superficial radiation therapy (SRT) with high resolution dermal ultrasound (HRDUS) to treat non-melanoma skin cancers (NMSC). Since development, IGSRT use has expanded dramatically in outpatient clinics. We review the IGSRT literature and state of the art operating principles in US dermatologic practices. Materials and Methods A literature search of electronic databases (Medline, Pubmed, Cochrane Library, Science Direct) combined with various authors’ published and unpublished documents, procedures and clinical experience with IGSRT were synthesized for this paper. Results Studies have demonstrated IGSRT consistently delivers high cure rates( >99%) with low complications for early stage (stage 0, I, or II) squamous cell and basal cell carcinomas. Control rates are statistically superior to non-image guided SRT and external beam radiation (XRT) as well as Mohs Micrographic Surgery(MMS). This improvement is attributed to in-vivo dermal tumor visualization via HRDUS and using an interdisciplinary approach to deliver care. IGSRT use in the dermatologic clinic for early stage NMSCs has become common practice and continues to expand. Conclusion While the safety and cosmetic benefits of SRT/XRT has been long documented, IGSRT represents a significant leap forward in efficacy (statistically significant) by adding in-vivo dermal tumor imaging. Results rival and appear on one study to surpass tumor control obtained with MMS. A contributing factor to the success may be the availability and use of an interdisciplinary team approach that includes dermatologists, radiation therapists, radiation oncologists and medical physicists. The high tumor control rates, minimal side effects, favorable cosmesis and ability to treat multiple lesions per session using IGSRT is establishing this modality as a standard first line therapy for early stage NMSCs in dermatology clinics. IGSRT may represent the most effective option for the non-surgical treatment of early stage NMSC to date.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
