Version 1
: Received: 12 August 2024 / Approved: 12 August 2024 / Online: 12 August 2024 (23:56:16 CEST)
How to cite:
Mendoza, M. A. O.; Escamilla, G. M.; Tavera-Hernández, R.; Sánchez-Obregón, R.; Toscano, R. A.; Enríquez, R. G. The First Homoleptic Geometrical Anti-zn Complex from an Unsymmetric Curcuminoid. Preprints2024, 2024080855. https://doi.org/10.20944/preprints202408.0855.v1
Mendoza, M. A. O.; Escamilla, G. M.; Tavera-Hernández, R.; Sánchez-Obregón, R.; Toscano, R. A.; Enríquez, R. G. The First Homoleptic Geometrical Anti-zn Complex from an Unsymmetric Curcuminoid. Preprints 2024, 2024080855. https://doi.org/10.20944/preprints202408.0855.v1
Mendoza, M. A. O.; Escamilla, G. M.; Tavera-Hernández, R.; Sánchez-Obregón, R.; Toscano, R. A.; Enríquez, R. G. The First Homoleptic Geometrical Anti-zn Complex from an Unsymmetric Curcuminoid. Preprints2024, 2024080855. https://doi.org/10.20944/preprints202408.0855.v1
APA Style
Mendoza, M. A. O., Escamilla, G. M., Tavera-Hernández, R., Sánchez-Obregón, R., Toscano, R. A., & Enríquez, R. G. (2024). The First Homoleptic Geometrical Anti-zn Complex from an Unsymmetric Curcuminoid. Preprints. https://doi.org/10.20944/preprints202408.0855.v1
Chicago/Turabian Style
Mendoza, M. A. O., Rubén A. Toscano and Raúl G. Enríquez. 2024 "The First Homoleptic Geometrical Anti-zn Complex from an Unsymmetric Curcuminoid" Preprints. https://doi.org/10.20944/preprints202408.0855.v1
Abstract
Curcuminoids are widely studied due to their well-recognized therapeutic properties. These molecules are often derivatized with metals, rendering their corresponding homoleptic metal complexes. Numerous crystal structures of homoleptic symmetric curcuminoids with physiologically essential metals are known, although the literature lacks reports of homoleptic unsymmetric metal complexes of curcuminoids (or hemi-curcuminoids). Two unknowns must be solved when an unsymmetric curcuminoid ligand is reacted with a metal ion: a) the degree of coordination (MLn) and b) the conformational nature (syn or anti) of the complex. Herein, we report the structure of the anti-isomer of the Zn complex of the hemi-curcuminoid 5-hydroxy-1-(4-methoxyphenyl)hexa-1,4-dien-3-one. While the NMR shows only one set of signals for this homoleptic complex, the unambiguous stereochemistry was established through single-crystal X-ray diffractometry, revealing a hexacoordinated ML2 structure.
Keywords
Hemi-curcuminoids; curcuminoids; homoleptic zinc metal complex; unsymmetric zinc complex
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
