Version 1
: Received: 10 August 2024 / Approved: 13 August 2024 / Online: 13 August 2024 (13:03:55 CEST)
How to cite:
Marques, B. D. C.; Banho, C. A.; Sacchetto, L.; Negri, A.; Vasilakis, N.; Nogueira, M. L. Impact of Vaccination on Intra-host Genetic Diversity of Patients Infected with SARS-CoV-2 Gamma Lineage. Preprints2024, 2024080940. https://doi.org/10.20944/preprints202408.0940.v1
Marques, B. D. C.; Banho, C. A.; Sacchetto, L.; Negri, A.; Vasilakis, N.; Nogueira, M. L. Impact of Vaccination on Intra-host Genetic Diversity of Patients Infected with SARS-CoV-2 Gamma Lineage. Preprints 2024, 2024080940. https://doi.org/10.20944/preprints202408.0940.v1
Marques, B. D. C.; Banho, C. A.; Sacchetto, L.; Negri, A.; Vasilakis, N.; Nogueira, M. L. Impact of Vaccination on Intra-host Genetic Diversity of Patients Infected with SARS-CoV-2 Gamma Lineage. Preprints2024, 2024080940. https://doi.org/10.20944/preprints202408.0940.v1
APA Style
Marques, B. D. C., Banho, C. A., Sacchetto, L., Negri, A., Vasilakis, N., & Nogueira, M. L. (2024). Impact of Vaccination on Intra-host Genetic Diversity of Patients Infected with SARS-CoV-2 Gamma Lineage. Preprints. https://doi.org/10.20944/preprints202408.0940.v1
Chicago/Turabian Style
Marques, B. D. C., Nikos Vasilakis and Maurício Lacerda Nogueira. 2024 "Impact of Vaccination on Intra-host Genetic Diversity of Patients Infected with SARS-CoV-2 Gamma Lineage" Preprints. https://doi.org/10.20944/preprints202408.0940.v1
Abstract
The high transmissibility, rapid evolution, and immune escape of SARS-CoV-2 variants can influence the course of infection and, in turn, morbidity and mortality in COVID-19, posing a challenge in controlling transmission rates and contributing to the emergence and spread of new variants. The factors that shape viral genetic variation are consequently essential for understanding the evolution and transmission of SARS-CoV-2, especially in vaccinated individuals where immune response plays a role in the progression and spread of this disease. This study assessed. In this context, we evaluated the impact of immunity induced by the CoronaVac vaccine (Butantan/Sinovac) on intra-host genetic diversity, analyzing 118 whole-genome sequences of SARS-CoV-2 from unvaccinated and vaccinated patients infected with the Gamma variant. Vaccination with CoronaVac favors negative selection at the intra-host level in different genomic regions and prevent greater genetic diversity of SARS-CoV-2, which may help reduce the emergence of new mutations, reinforcing the importance of vaccination in reducing virus transmission.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
