Preprint Article Version 1 This version is not peer-reviewed

Relationship of Serum Zonulin Level with Renal Functions, Systemic Inflammation and Endothelial Dysfunction in Patients with Chronic Kidney Disease

Version 1 : Received: 14 August 2024 / Approved: 14 August 2024 / Online: 14 August 2024 (11:54:08 CEST)

How to cite: Kirik, A.; Toprak, O.; Sen, H.; Uysal, S.; Kocyigit, S. E.; Bilgicler, İ.; Parlak, E.; Mutlu, T.; Bascı, O. K. Relationship of Serum Zonulin Level with Renal Functions, Systemic Inflammation and Endothelial Dysfunction in Patients with Chronic Kidney Disease. Preprints 2024, 2024081055. https://doi.org/10.20944/preprints202408.1055.v1 Kirik, A.; Toprak, O.; Sen, H.; Uysal, S.; Kocyigit, S. E.; Bilgicler, İ.; Parlak, E.; Mutlu, T.; Bascı, O. K. Relationship of Serum Zonulin Level with Renal Functions, Systemic Inflammation and Endothelial Dysfunction in Patients with Chronic Kidney Disease. Preprints 2024, 2024081055. https://doi.org/10.20944/preprints202408.1055.v1

Abstract

Background and Objectives: Zonulin is a molecule that has been identified as an intestinal permeability marker in recent years. Zonulin previously linked to Diabetes Mellitus, Obesity and Cardiovascular Disease but but its role in chronic kidney disease (CKD) was unclear. This study aims to investigate the relationship between Zonulin and systemic inflammation (SI), endothelial dysfunction (ED), especially renal functions, in patients with CKD. Materials and Methods: One hundred sixty-three participants were enrolled in this study. All participants were divided into two groups, patient and control groups, according to the presence of CKD (eGFR

Keywords

Zonulin; chronic kidney disease; systemic inflammation; endothelial dysfunction

Subject

Medicine and Pharmacology, Urology and Nephrology

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