Version 1
: Received: 16 August 2024 / Approved: 16 August 2024 / Online: 16 August 2024 (17:11:59 CEST)
How to cite:
Takanen, S.; Ianiro, A.; Pinnaro, P.; Infusino, E.; Marucci, L.; Soriani, A.; Sanguineti, G.; Iaccarino, G. A Customized 3D Printed Bolus for High‐Risk Breast Cancer with Skin Infiltration: A Pilot Study. Preprints2024, 2024081253. https://doi.org/10.20944/preprints202408.1253.v1
Takanen, S.; Ianiro, A.; Pinnaro, P.; Infusino, E.; Marucci, L.; Soriani, A.; Sanguineti, G.; Iaccarino, G. A Customized 3D Printed Bolus for High‐Risk Breast Cancer with Skin Infiltration: A Pilot Study. Preprints 2024, 2024081253. https://doi.org/10.20944/preprints202408.1253.v1
Takanen, S.; Ianiro, A.; Pinnaro, P.; Infusino, E.; Marucci, L.; Soriani, A.; Sanguineti, G.; Iaccarino, G. A Customized 3D Printed Bolus for High‐Risk Breast Cancer with Skin Infiltration: A Pilot Study. Preprints2024, 2024081253. https://doi.org/10.20944/preprints202408.1253.v1
APA Style
Takanen, S., Ianiro, A., Pinnaro, P., Infusino, E., Marucci, L., Soriani, A., Sanguineti, G., & Iaccarino, G. (2024). A Customized 3D Printed Bolus for High‐Risk Breast Cancer with Skin Infiltration: A Pilot Study. Preprints. https://doi.org/10.20944/preprints202408.1253.v1
Chicago/Turabian Style
Takanen, S., Giuseppe Sanguineti and Giuseppe Iaccarino. 2024 "A Customized 3D Printed Bolus for High‐Risk Breast Cancer with Skin Infiltration: A Pilot Study" Preprints. https://doi.org/10.20944/preprints202408.1253.v1
Abstract
Background: In high-risk breast cancer patients with skin infiltration the administration of a uniform dose to superficial tissues is fundamental in order to reduce local skin relapse. A personalized bolus may prevent the potential standard bolus’ inadequate dose distribution due to air gaps between the bolus and the skin. In this pilot study, we introduced in clinical practice the use of a personalized 3D printed bolus filled with ultrasound transmission gel. Methods: Seven patients undergoing radiotherapy after mastectomy were selected. 3D printed bolus dosimetric assessment was performed with MOSFET dosimeters on an anthropomorphic phantom and subsequently on three selected cases with increasing bolus shape irregularity. Acute/late toxicity and local control was assessed. Results: Overall, for the clinical cases the percentage median difference between measured and calculated doses was -2.7% (-7.0%÷4.9%). Median follow-up was 21 months. After two years, one patient showed G2 pain, one patient manifested G1 telangiectasia, one patient showed G1 hyperpigmentation, and two patients had no relevant toxicity. Conclusions: Personalized 3D-printed bolus filled with ultrasound gel may easily reproduce the standard bolus’ consistency providing an accurate coverage of the target area with tolerable acute/late toxicity grades. This is a pilot study and further investigations are needed.
Keywords
breast cancer; skin toxicity; dosimetric analysis; 3D printed bolus
Subject
Medicine and Pharmacology, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
