Therapeutic Vaccination in Chronic Hepatitis B: A Systematic Assessment by the HeberNasvac Therapeutic Vaccine Team

Julio Cesar Aguilar; Sheikh Mohammad Fazle Akbar; Mamun Al-Mahtab; Carlos Alberto Guzman; Guillermo Fernandez; Jorge Aguiar; Marie-Louise Michel; Maryline Bourgine; Maria Acelia Marrero; Stephanie Trittel; Thomas Ebensen; Peggy Riese; Roger LeGrand; Cecile Herate; Aurelie Mauras; Heiner Wedemeyer; Osamu Yoshida; Yoichi Hiasa; Eduardo Penton; Gerardo Guillen

doi:10.20944/preprints202408.1272.v1

How to cite: Aguilar, J. C.; Akbar, S. M. F.; Al-Mahtab, M.; Guzman, C. A.; Fernandez, G.; Aguiar, J.; Michel, M.-L.; Bourgine, M.; Acelia Marrero, M.; Trittel, S.; Ebensen, T.; Riese, P.; LeGrand, R.; Herate, C.; Mauras, A.; Wedemeyer, H.; Yoshida, O.; Hiasa, Y.; Penton, E.; Guillen, G. Therapeutic Vaccination in Chronic Hepatitis B: A Systematic Assessment by the HeberNasvac Therapeutic Vaccine Team. Preprints 2024, 2024081272. https://doi.org/10.20944/preprints202408.1272.v1 Aguilar, J. C.; Akbar, S. M. F.; Al-Mahtab, M.; Guzman, C. A.; Fernandez, G.; Aguiar, J.; Michel, M.-L.; Bourgine, M.; Acelia Marrero, M.; Trittel, S.; Ebensen, T.; Riese, P.; LeGrand, R.; Herate, C.; Mauras, A.; Wedemeyer, H.; Yoshida, O.; Hiasa, Y.; Penton, E.; Guillen, G. Therapeutic Vaccination in Chronic Hepatitis B: A Systematic Assessment by the HeberNasvac Therapeutic Vaccine Team. Preprints 2024, 2024081272. https://doi.org/10.20944/preprints202408.1272.v1

Abstract

The immune system is central in controlling acute hepatitis B infection and in patients resolving chronic hepatitis B (CHB). Given that 221 million (75%) of CHB patients reside in low- and middle-income countries, developing a vaccine with therapeutic properties represents a rational and cost-effective approach more than a romantic endeavor. This review systematically analyses the critical variables related to the safety, efficacy, and effectiveness of CHB treatments. HeberNasvac's experience is revisited to address the challenges and potentialities of therapeutic vaccines, as well as the current roadblocks in research and development, registration, and large-scale implementation.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Therapeutic Vaccination in Chronic Hepatitis B: A Systematic Assessment by the HeberNasvac Therapeutic Vaccine Team

Abstract

Keywords

Subject

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