Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind

Daniel Guerreiro Diniz; João Bento-Torres; Victor Oliveira Da Costa; Josilayne Patrícia Ramos Carvalho; Alessandra Mendonça Tomás; Thaís Cristina Galdino de Oliveira; Fernanda Cabral Soares; Liliane Dias e Dias de Macedo; Naina Yuki Vieira Jardim; Natáli Valim Oliver Bento-Torres; Daniel C. Anthony; Dora Brites; Cristovam Wanderley Picanço-Diniz

doi:10.20944/preprints202408.1277.v1

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preprints.org > biology and life sciences > aging > doi: 10.20944/preprints202408.1277.v1 (registering DOI)

Preprint Review Version 1 This version is not peer-reviewed

Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind

Daniel Guerreiro Diniz

João Bento-Torres

Victor Oliveira Da Costa

Josilayne Patrícia Ramos Carvalho

Alessandra Mendonça Tomás

Thaís Cristina Galdino de Oliveira

Fernanda Cabral Soares

Liliane Dias e Dias de Macedo

Naina Yuki Vieira Jardim

Natáli Valim Oliver Bento-Torres

Daniel C. Anthony

Dora Brites

Cristovam Wanderley Picanço-Diniz

Version 1 : Received: 17 August 2024 / Approved: 18 August 2024 / Online: 20 August 2024 (05:12:12 CEST)

How to cite: Diniz, D. G.; Bento-Torres, J.; Da Costa, V. O.; Carvalho, J. P. R.; Tomás, A. M.; Galdino de Oliveira, T. C.; Soares, F. C.; de Macedo, L. D. E. D.; Jardim, N. Y. V.; Bento-Torres, N. V. O.; Anthony, D. C.; Brites, D.; Picanço-Diniz, C. W. Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind. Preprints 2024, 2024081277. https://doi.org/10.20944/preprints202408.1277.v1 Diniz, D. G.; Bento-Torres, J.; Da Costa, V. O.; Carvalho, J. P. R.; Tomás, A. M.; Galdino de Oliveira, T. C.; Soares, F. C.; de Macedo, L. D. E. D.; Jardim, N. Y. V.; Bento-Torres, N. V. O.; Anthony, D. C.; Brites, D.; Picanço-Diniz, C. W. Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind. Preprints 2024, 2024081277. https://doi.org/10.20944/preprints202408.1277.v1

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MDPI and ACS Style

Diniz, D. G.; Bento-Torres, J.; Da Costa, V. O.; Carvalho, J. P. R.; Tomás, A. M.; Galdino de Oliveira, T. C.; Soares, F. C.; de Macedo, L. D. E. D.; Jardim, N. Y. V.; Bento-Torres, N. V. O.; Anthony, D. C.; Brites, D.; Picanço-Diniz, C. W. Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind. Preprints 2024, 2024081277. https://doi.org/10.20944/preprints202408.1277.v1

APA Style

Diniz, D. G., Bento-Torres, J., Da Costa, V. O., Carvalho, J. P. R., Tomás, A. M., Galdino de Oliveira, T. C., Soares, F. C., de Macedo, L. D. E. D., Jardim, N. Y. V., Bento-Torres, N. V. O., Anthony, D. C., Brites, D., & Picanço-Diniz, C. W. (2024). Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind. Preprints. https://doi.org/10.20944/preprints202408.1277.v1

Chicago/Turabian Style

Diniz, D. G., Dora Brites and Cristovam Wanderley Picanço-Diniz. 2024 "Sedentary Life Is an Invisible Trap: Molecular, Cellular, and Systemic Reasons to Leave It Behind" Preprints. https://doi.org/10.20944/preprints202408.1277.v1

Abstract

As the global population ages, the prevalence of neurodegenerative diseases has become a major public health concern. The adoption of a less sedentary lifestyle has been shown to have a beneficial effect on cognitive decline, but the molecular mechanisms responsible are less clear. Here we provide a detailed analysis of the complex molecular, cellular, and systemic mechanisms underlying age-related cognitive decline and how lifestyle choices influence these processes. A review of the evidence from animal models, human studies, and postmortem analyses emphasizes the importance of integrating physical exercise with cognitive, multisensory, and motor stimulation as part of a multifaceted approach to mitigating cognitive decline. We highlight the potential of these non-pharmacological interventions to address key aging hallmarks—such as genomic instability, telomere attrition, and neuroinflammation—and underscore the need for comprehensive and personalized strategies to promote cognitive resilience and healthy aging.

Keywords

Age-related cognitive decline; epigenetics; immunosenescence; neurodegeneration; neuron-glia crosstalk; neuroinflammation and oxidative stress; physical exercise; protein aggregation; non-pharmacological and therapeutic interventions; synaptic dysfunction

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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