Version 1
: Received: 16 August 2024 / Approved: 19 August 2024 / Online: 19 August 2024 (09:49:25 CEST)
How to cite:
Abd Razak, N. H.; Idris, J.; Hassan, N. H.; Zaini, F.; Muhamad, N.; Daud, M. F. Unveiling the Role of Schwann Cell Plasticity in the Pathogenesis of Diabetic Peripheral Neuropathy. Preprints2024, 2024081297. https://doi.org/10.20944/preprints202408.1297.v1
Abd Razak, N. H.; Idris, J.; Hassan, N. H.; Zaini, F.; Muhamad, N.; Daud, M. F. Unveiling the Role of Schwann Cell Plasticity in the Pathogenesis of Diabetic Peripheral Neuropathy. Preprints 2024, 2024081297. https://doi.org/10.20944/preprints202408.1297.v1
Abd Razak, N. H.; Idris, J.; Hassan, N. H.; Zaini, F.; Muhamad, N.; Daud, M. F. Unveiling the Role of Schwann Cell Plasticity in the Pathogenesis of Diabetic Peripheral Neuropathy. Preprints2024, 2024081297. https://doi.org/10.20944/preprints202408.1297.v1
APA Style
Abd Razak, N. H., Idris, J., Hassan, N. H., Zaini, F., Muhamad, N., & Daud, M. F. (2024). Unveiling the Role of Schwann Cell Plasticity in the Pathogenesis of Diabetic Peripheral Neuropathy. Preprints. https://doi.org/10.20944/preprints202408.1297.v1
Chicago/Turabian Style
Abd Razak, N. H., Noorzaid Muhamad and Muhammad Fauzi Daud. 2024 "Unveiling the Role of Schwann Cell Plasticity in the Pathogenesis of Diabetic Peripheral Neuropathy" Preprints. https://doi.org/10.20944/preprints202408.1297.v1
Abstract
Diabetic peripheral neuropathy (DPN) is a prevalent complication of type 2 diabetes that affects a significant proportion of diabetic patients worldwide. Although the pathogenesis of DPN involves axonal atrophy and demyelination, the exact mechanisms remain elusive. Current research has predominantly focused on neuronal damage, overlooking the potential contributions of Schwann cells, which are the predominant glial cells in the peripheral nervous system. Schwann cells play a critical role in neurodevelopment, neurophysiology, and nerve regeneration. This review highlights the emerging understanding of the involvement of Schwann cells in DPN pathogenesis. This review explores the potential role of Schwann cell plasticity as an underlying cellular and molecular mechanism in the development of DPN. Understanding the interplay between Schwann cell plasticity and diabetes could reveal novel strategies for the treatment and management of DPN.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
