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Synthesis of poly(L-Lactide)–Poly(-Caprolactone)–Poly(ethylene Glycol) Terpolymer Grafted onto Partially Oxidized Carbon Nanotube Nanocomposites for Drug Delivery
Version 1
: Received: 17 August 2024 / Approved: 19 August 2024 / Online: 19 August 2024 (13:01:42 CEST)
How to cite:
González-Iñiguez, K. J.; Figueroa-Ochoa, E. B.; Martínez-Richa, A.; Cajero-Zul, L. R.; Nuño-Donlucas, S. M. Synthesis of poly(L-Lactide)–Poly(-Caprolactone)–Poly(ethylene Glycol) Terpolymer Grafted onto Partially Oxidized Carbon Nanotube Nanocomposites for Drug Delivery. Preprints2024, 2024081347. https://doi.org/10.20944/preprints202408.1347.v1
González-Iñiguez, K. J.; Figueroa-Ochoa, E. B.; Martínez-Richa, A.; Cajero-Zul, L. R.; Nuño-Donlucas, S. M. Synthesis of poly(L-Lactide)–Poly(-Caprolactone)–Poly(ethylene Glycol) Terpolymer Grafted onto Partially Oxidized Carbon Nanotube Nanocomposites for Drug Delivery. Preprints 2024, 2024081347. https://doi.org/10.20944/preprints202408.1347.v1
González-Iñiguez, K. J.; Figueroa-Ochoa, E. B.; Martínez-Richa, A.; Cajero-Zul, L. R.; Nuño-Donlucas, S. M. Synthesis of poly(L-Lactide)–Poly(-Caprolactone)–Poly(ethylene Glycol) Terpolymer Grafted onto Partially Oxidized Carbon Nanotube Nanocomposites for Drug Delivery. Preprints2024, 2024081347. https://doi.org/10.20944/preprints202408.1347.v1
APA Style
González-Iñiguez, K. J., Figueroa-Ochoa, E. B., Martínez-Richa, A., Cajero-Zul, L. R., & Nuño-Donlucas, S. M. (2024). Synthesis of poly(L-Lactide)–Poly(-Caprolactone)–Poly(ethylene Glycol) Terpolymer Grafted onto Partially Oxidized Carbon Nanotube Nanocomposites for Drug Delivery. Preprints. https://doi.org/10.20944/preprints202408.1347.v1
Chicago/Turabian Style
González-Iñiguez, K. J., Leonardo R. Cajero-Zul and Sergio M. Nuño-Donlucas. 2024 "Synthesis of poly(L-Lactide)–Poly(-Caprolactone)–Poly(ethylene Glycol) Terpolymer Grafted onto Partially Oxidized Carbon Nanotube Nanocomposites for Drug Delivery" Preprints. https://doi.org/10.20944/preprints202408.1347.v1
Abstract
Nanocomposites prepared with a terpolymer of poly(L-lactide) (PLLA)–poly(-caprolactone) (PCL)–poly(ethylene glycol) (PEG) and partially oxidized carbon nanotubes (CNTspo) were synthesized and characterized to evaluate their ability to act as an effective nanocarrier of the anticancer drug methotrexate. The homopolymers of PLLA and PCL were synthesized through ring-opening polymerization (ROP) and characterized through gel permeation chromatography (GPC). The PLLA–PCL–PEG terpolymers were synthesized through a four-step chemical route using oxalyl chloride as a linker agent and analyzed through 1H-NMR, 13C-NMR, and FT-IR spectroscopies. Also, the nanocomposites were characterized through FT-IR, 1H-NMR, and X-ray photoelectron spectroscopy (XPS) spectroscopies and, using the differential scanning calorimetry (DSC) technique. XPS analysis revealed that CNTspo is grafted to PLLA–PCL–PEG terpolymer. Besides, evaluation through FT-IR and DSC strongly suggests that the CNTspo are preferentially oriented to the PCL-rich domains. The release tests exhibited a “burst effect” profile, which was more evident in the terpolymers than in the nanocomposites. Five models were used to assess the methotrexate in vitro release. For the nanocomposites, the best fit to the experimental data was obtained using the first-order model, whereas the results obtained from the Korsmeyer–Peppas model indicated that a Fickian diffusion drives the methotrexate release.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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