Version 1
: Received: 19 August 2024 / Approved: 19 August 2024 / Online: 21 August 2024 (02:28:54 CEST)
How to cite:
Khalifa, M. E.; Ayllón, M. A.; Rodriguez-Coy, L.; Plummer, K. M.; Gendall, A. R.; Chooi, K. M.; van Kan, J. A.; MacDiarmid, R. M. Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Study. Preprints2024, 2024081370. https://doi.org/10.20944/preprints202408.1370.v1
Khalifa, M. E.; Ayllón, M. A.; Rodriguez-Coy, L.; Plummer, K. M.; Gendall, A. R.; Chooi, K. M.; van Kan, J. A.; MacDiarmid, R. M. Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Study. Preprints 2024, 2024081370. https://doi.org/10.20944/preprints202408.1370.v1
Khalifa, M. E.; Ayllón, M. A.; Rodriguez-Coy, L.; Plummer, K. M.; Gendall, A. R.; Chooi, K. M.; van Kan, J. A.; MacDiarmid, R. M. Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Study. Preprints2024, 2024081370. https://doi.org/10.20944/preprints202408.1370.v1
APA Style
Khalifa, M. E., Ayllón, M. A., Rodriguez-Coy, L., Plummer, K. M., Gendall, A. R., Chooi, K. M., van Kan, J. A., & MacDiarmid, R. M. (2024). Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Study. Preprints. https://doi.org/10.20944/preprints202408.1370.v1
Chicago/Turabian Style
Khalifa, M. E., Jan A.L. van Kan and Robin M MacDiarmid. 2024 "Mycologists and Virologists Align: Proposing Botrytis cinerea for Global Mycovirus Study" Preprints. https://doi.org/10.20944/preprints202408.1370.v1
Abstract
Mycoviruses are highly genetically diverse, can significantly change their fungal host’s phenotype, yet, they are generally under-described in genotypic and biological studies. We propose Botrytis cinerea as a model mycovirus system in which to develop a deeper understanding of mycovirus epidemiology including diversity, impact, and the associated cellular biology of the host and virus interaction. Over 100 mycoviruses have been described in this fungal host. B. cinerea is an ideal model fungus for mycovirology as it has highly tractable characteristics – it is easy to culture, has a worldwide distribution, infects a wide range of host plants, can be transformed and gene-edited, and has an existing depth of biological resources including annotated genomes, transcriptomes, and isolates with gene knockouts. Focus on a model system for mycoviruses will enable the research community to address deep research questions that cannot be answered in a non-systematic manner. Since B. cinerea is a major plant pathogen, new insights may have immediate utility as well as creating new knowledge that complements and extends the knowledge of mycovirus interactions in other fungi, alone or with their respective plant hosts. In this review we set out some of the critical steps required to develop B. cinerea as a model mycovirus system and how this may be used in the future.
Keywords
model system; Botrytis cinerea; mycovirus
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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