Version 1
: Received: 19 August 2024 / Approved: 20 August 2024 / Online: 21 August 2024 (10:16:33 CEST)
How to cite:
Stack, E. H.; Okar, S. V.; Wu, T.; Stack, M.; Mina, Y.; Gaitan, M. I.; Azodi, S.; Frazier, W.; Ohayon, J.; Cortese, I.; Reich, D. S.; Nair, G.; Jacobson, S. Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Preprints2024, 2024081469. https://doi.org/10.20944/preprints202408.1469.v1
Stack, E. H.; Okar, S. V.; Wu, T.; Stack, M.; Mina, Y.; Gaitan, M. I.; Azodi, S.; Frazier, W.; Ohayon, J.; Cortese, I.; Reich, D. S.; Nair, G.; Jacobson, S. Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Preprints 2024, 2024081469. https://doi.org/10.20944/preprints202408.1469.v1
Stack, E. H.; Okar, S. V.; Wu, T.; Stack, M.; Mina, Y.; Gaitan, M. I.; Azodi, S.; Frazier, W.; Ohayon, J.; Cortese, I.; Reich, D. S.; Nair, G.; Jacobson, S. Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Preprints2024, 2024081469. https://doi.org/10.20944/preprints202408.1469.v1
APA Style
Stack, E. H., Okar, S. V., Wu, T., Stack, M., Mina, Y., Gaitan, M. I., Azodi, S., Frazier, W., Ohayon, J., Cortese, I., Reich, D. S., Nair, G., & Jacobson, S. (2024). Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Preprints. https://doi.org/10.20944/preprints202408.1469.v1
Chicago/Turabian Style
Stack, E. H., Govind Nair and Steven Jacobson. 2024 "Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)" Preprints. https://doi.org/10.20944/preprints202408.1469.v1
Abstract
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive neurological disorder and shares many radiological and clinical features with other more prevalent myelopathies. Here, we quantified spinal cord and brain volumes in adults with HAM/TSP in comparison with healthy volunteers (HVs) and participants diagnosed with multiple sclerosis (MS). Clinical disability and MRI were assessed in 24 HVs, 43 HAM/TSP, and 46 MS participants. Spinal cord cross-sectional area (SCCSA) and brain tissue volumes were measured and compared. HAM/TSP participants had significantly lower SCCSA at C2-3 (54.0±8 mm2), C4-5 (57.8±8 mm2), and T4-9 (22.7±4 mm2) and significantly elevated brain white matter hyperintensity (WMH) fraction (0.004±0.008) was compared to HVs (C2-3: 69.4±8 mm2, C4-5: 75.1±9 mm2, T4-9: 34.1±4 mm2; all p < 0.0001; and WMH: 0.0004±0.0007; p < 0.001). In HAM/TSP, SCCSA at all levels but not WMH showed the significant correlation with clinical disability scores. Brain white matter hyperintensities in HAM/TSP, therefore, may not be related to clinical disability. SCCSA and WMH in our limited MS cohort were higher than the HAM/TSP cohort (67.6±8 mm2, 72.7±9 mm2, 33.4±5 mm2; p < 0.0001). Principal component analysis suggested that SCCSA and WMH may be used to differentiated HAM/TSP from MS. Understanding these differences may help establish early diagnostic criteria for HAM/TSP patients.
Keywords
central nervous system atrophy; spinal cord atrophy; white matter hyperintensities; magnetic resonance imaging; HTLV-1-associated myelopathy
Subject
Public Health and Healthcare, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
