Version 1
: Received: 21 August 2024 / Approved: 21 August 2024 / Online: 22 August 2024 (12:21:44 CEST)
How to cite:
Rajkumar, R. P. Telomere Length and Telomerase in Post-Traumatic Stress Disorder: An Update and a Reappraisal of the Evidence. Preprints2024, 2024081584. https://doi.org/10.20944/preprints202408.1584.v1
Rajkumar, R. P. Telomere Length and Telomerase in Post-Traumatic Stress Disorder: An Update and a Reappraisal of the Evidence. Preprints 2024, 2024081584. https://doi.org/10.20944/preprints202408.1584.v1
Rajkumar, R. P. Telomere Length and Telomerase in Post-Traumatic Stress Disorder: An Update and a Reappraisal of the Evidence. Preprints2024, 2024081584. https://doi.org/10.20944/preprints202408.1584.v1
APA Style
Rajkumar, R. P. (2024). Telomere Length and Telomerase in Post-Traumatic Stress Disorder: An Update and a Reappraisal of the Evidence. Preprints. https://doi.org/10.20944/preprints202408.1584.v1
Chicago/Turabian Style
Rajkumar, R. P. 2024 "Telomere Length and Telomerase in Post-Traumatic Stress Disorder: An Update and a Reappraisal of the Evidence" Preprints. https://doi.org/10.20944/preprints202408.1584.v1
Abstract
Post-traumatic stress disorder (PTSD), a mental disorder caused by exposure to traumatic stress, affects 5-10% of the world’s population. PTSD is associated with several medical and neurological comorbidities. It has been suggested that these are due to accelerated aging, and that changes in telomere length (TL) and telomerase enzyme activity may serve as biomarkers of this process. Early research in this field suggested that TL was significantly reduced in PTSD. The current review was conducted to provide a critical analysis of recent clinical and translational research on telomere length and telomerase in PTSD. The results of 26 clinical studies suggest that TL in PTSD is highly variable, and may be influenced by methodological, demographic, trauma-related and psychosocial factors. There is no evidence for altered telomerase activity in PTSD, though this was hypothesized by earlier workers in the field. Translational research suggests that exposure to traumatic stress does lead to TL shortening. Overall, it is likely that TL in PTSD depends on several variables that are specific to individuals and groups. Other markers of cellular aging, such as epigenetic changes, may be more specific indices of accelerated aging in patients with PTSD.
Medicine and Pharmacology, Psychiatry and Mental Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
