Version 1
: Received: 21 August 2024 / Approved: 21 August 2024 / Online: 21 August 2024 (17:03:39 CEST)
How to cite:
Nassar, S. I.; Suk, A.; Nguyen, S. A.; Adilbay, D.; Pang, J.; Nathan, C.-A. O. The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine. Preprints2024, 2024081590. https://doi.org/10.20944/preprints202408.1590.v1
Nassar, S. I.; Suk, A.; Nguyen, S. A.; Adilbay, D.; Pang, J.; Nathan, C.-A. O. The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine. Preprints 2024, 2024081590. https://doi.org/10.20944/preprints202408.1590.v1
Nassar, S. I.; Suk, A.; Nguyen, S. A.; Adilbay, D.; Pang, J.; Nathan, C.-A. O. The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine. Preprints2024, 2024081590. https://doi.org/10.20944/preprints202408.1590.v1
APA Style
Nassar, S. I., Suk, A., Nguyen, S. A., Adilbay, D., Pang, J., & Nathan, C. A. O. (2024). The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine. Preprints. https://doi.org/10.20944/preprints202408.1590.v1
Chicago/Turabian Style
Nassar, S. I., John Pang and Cherie-Ann O. Nathan. 2024 "The Role of ctDNA and Liquid Biopsy in the Diagnosis and Monitoring of Head and Neck Cancer: Towards Precision Medicine" Preprints. https://doi.org/10.20944/preprints202408.1590.v1
Abstract
Recent data has shown a continued rise in the worldwide annual incidence and mortality rates of head and neck cancers. The present standard for diagnosis and monitoring for disease recurrence or progression involves clinical examination, imaging, and invasive biopsy techniques of lesions suspected of being malignant. In addition to limitations relating to cost, time, and patient discomfort, these methodologies have inherent inaccuracies for detecting recurrence. In view of these limitations, the analysis of patient bodily fluid samples via liquid biopsy proposes a cost-effective and convenient alternative, which provides insight on the biogenetic and biomolecular underpinnings of oncologic disease processes. Liquid biopsy’s monitoring for biomarkers of head and neck cancer, including circulating tumor DNA, circulating tumor cells, and circulating cell-free RNA, has shown clinical utility in the screening, diagnosis, prognostication, and monitoring of patients with various forms of head and neck cancer. The present review will provide an update on the current literature examining the use of liquid biopsy in head and neck cancer care and the clinical applicability of potential biomarkers, with a focus on viral and non-viral circulating tumor DNA. Possible future avenues for research to address specific shortcomings of liquid biopsy will be discussed.
Keywords
head and neck cancer; liquid biopsy; ctDNA; squamous cell carcinoma; oropharyngeal carcinoma; nasopharyngeal carcinoma; genetic mutations; genomic sequencing; cancer biomarkers
Subject
Medicine and Pharmacology, Otolaryngology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
