Version 1
: Received: 21 August 2024 / Approved: 22 August 2024 / Online: 22 August 2024 (08:25:55 CEST)
How to cite:
Liu, E.; Ji, X.; Zhou, K. Akkermansia muciniphila for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies. Preprints2024, 2024081618. https://doi.org/10.20944/preprints202408.1618.v1
Liu, E.; Ji, X.; Zhou, K. Akkermansia muciniphila for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies. Preprints 2024, 2024081618. https://doi.org/10.20944/preprints202408.1618.v1
Liu, E.; Ji, X.; Zhou, K. Akkermansia muciniphila for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies. Preprints2024, 2024081618. https://doi.org/10.20944/preprints202408.1618.v1
APA Style
Liu, E., Ji, X., & Zhou, K. (2024). <em>Akkermansia muciniphila</em> for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies. Preprints. https://doi.org/10.20944/preprints202408.1618.v1
Chicago/Turabian Style
Liu, E., Xiangming Ji and Kequan Zhou. 2024 "<em>Akkermansia muciniphila</em> for the Prevention of Type 2 Diabetes and Obesity: A Meta-Analysis of Animal Studies" Preprints. https://doi.org/10.20944/preprints202408.1618.v1
Abstract
More than half of the states in the U.S. report that over 30% of adults are obese. Obesity increases the risk of many chronic diseases, including type 2 diabetes, hypertension, cardiovascular disease, and can even reduce one’s lifespan. Similarly, the prevalence of type 2 diabetes follows a comparable trend. As a result, researchers are striving to find solutions to reduce obesity rates, with a particular focus on gut health, which has been previously linked to both obesity and type 2 diabetes. Recent studies suggest that Akkermansia muciniphila(AKK) may have a positive probiotic effect on preventing the onset of type 2 diabetes and obesity. We conducted a quantitative meta-analysis of 15 qualified animal studies investigating the effects of AKK administration as a probiotic. The statistical analyses showed that AKK administration significantly reduced body weight gain by 10.4% and fasting blood glucose by 21.2%, while also significantly improving glucose tolerance by 22.1% and increasing blood insulin levels by 26.9%. However, our analysis revealed substantial heterogeneity between the control and experimental groups across all subgroups. Overall, AKK appears to be effective at reducing the onset of type 2 diabetes and diet-induced obesity. Long-term studies with larger sample sizes are needed to confirm these beneficial effects, as the current animal studies were of short duration (less than 20 weeks).
Keywords
probiotic; Akkermansia; obesity; type 2 diabetes; animals; meta-analysis
Subject
Biology and Life Sciences, Food Science and Technology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.