Review
Version 1
This version is not peer-reviewed
New Role of the Serotonin as a Biomarker of Gut-Brain Interaction
Version 1
: Received: 23 August 2024 / Approved: 23 August 2024 / Online: 23 August 2024 (18:50:30 CEST)
How to cite: Liu, H. N.; Nakamura, M.; Kawashima, H. New Role of the Serotonin as a Biomarker of Gut-Brain Interaction. Preprints 2024, 2024081730. https://doi.org/10.20944/preprints202408.1730.v1 Liu, H. N.; Nakamura, M.; Kawashima, H. New Role of the Serotonin as a Biomarker of Gut-Brain Interaction. Preprints 2024, 2024081730. https://doi.org/10.20944/preprints202408.1730.v1
Abstract
Serotonin (5-hydroxytryptamine: 5-HT), a neurotransmitter that regulates mood in the brain and signaling in the gut, has receptors throughout the body that serve various functions. Selective serotonin reuptake inhibitors (SSRIs) are used to treat depression, but their efficacy is uncertain. Depression is often associated with early gastrointestinal symptoms. Gut disorders such as functional dyspepsia (FD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are linked to elevated serotonin levels. In this review, we would like to discuss the approach of using serotonin as a biomarker for gut-brain and body-wide organ communication may lead to the development of preventive and innovative treatments for gut-brain disorders, offering improved visibility and therapeutic monitoring. It could also be used to gauge stress intensity for self-care and mental health improvement.
Keywords
Serotonin; Gut-Brain Interaction; Biomarker; Mood; Irritable Bowel Syndrome (IBS); Inflammatory Bowel Disease (IBD); Functional Dyspepsia (FD); Cancer; Gut Homeostasis
Subject
Biology and Life Sciences, Life Sciences
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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