Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Metabolic Aging as an Increased Risk for Chronic Obstructive Pulmonary Disease

Claire Guo
,
Suneeta Godbole
ORCID logo ,
Wassim Labaki
,
Jeffrey L. Curtis
ORCID logo ,
Robert Paine
,
Eric Hoffman
,
Meilan Han
,
Jill Ohar
,
Christopher Cooper
,
Katerina Kechris
ORCID logo ,
Dawn L. DeMeo
,
Russell Bowler
* ORCID logo
Version 1 : Received: 23 August 2024 / Approved: 23 August 2024 / Online: 26 August 2024 (06:56:00 CEST)

How to cite: Guo, C.; Godbole, S.; Labaki, W.; Curtis, J. L.; Paine, R.; Hoffman, E.; Han, M.; Ohar, J.; Cooper, C.; Kechris, K.; DeMeo, D. L.; Bowler, R. Metabolic Aging as an Increased Risk for Chronic Obstructive Pulmonary Disease. Preprints 2024, 2024081779. https://doi.org/10.20944/preprints202408.1779.v1 Guo, C.; Godbole, S.; Labaki, W.; Curtis, J. L.; Paine, R.; Hoffman, E.; Han, M.; Ohar, J.; Cooper, C.; Kechris, K.; DeMeo, D. L.; Bowler, R. Metabolic Aging as an Increased Risk for Chronic Obstructive Pulmonary Disease. Preprints 2024, 2024081779. https://doi.org/10.20944/preprints202408.1779.v1

Abstract

Both aging and chronic obstructive pulmonary disease (COPD) are strongly associated with changes in the metabolome; however, it is unknown whether there are common aging/COPD metabolomic signatures and if accelerated aging is associated with COPD. Plasma from 5,704 subjects from COPDGene and 2,449 subjects from SPIROMICS were profiled using the Metabolon global metabolomics platform (1,013 annotated metabolites). Post-bronchodilator spirometry measures of airflow obstruction (forced expiratory volume at one second (FEV1)/forced vital capacity (FVC) < 0.7) were used to define COPD. Elastic net regression was trained on never and former smokers with normal spirometry and no emphysema to create a metabolomic age score which was validated in SPIROMICS subjects. Our metabolic age score was strongly associated with chronic age in the validation cohort (correlation coefficient 0.8). COPD subjects with accelerated aging (> 7 years difference between metabolic and actual age) had more severe disease compared with those who had decelerated aging (< -7 years difference between metabolic and actual age). COPD and aging metabolites were shared more than expected (P < 0.001) with overrepresented included amino acid and glutathione metabolism pathways. These findings suggesting a common mechanism between aging and COPD and that COPD is associated with accelerated metabolic aging.

Keywords

aging; COPD; metabolic age

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.