Version 1
: Received: 23 August 2024 / Approved: 23 August 2024 / Online: 26 August 2024 (11:03:48 CEST)
How to cite:
Jiménez-Franco, A.; Jiménez-Aguilar, J. M.; Canela-Capdevila, M.; García-Pablo, R.; Castañé, H.; Martínez-Navidad, C.; Araguas, P.; Malavé, B.; Benavides-Villarreal, R.; Acosta, J. C.; Onoiu, A. I.; Somaiah, N.; Camps, J.; Joven, J.; Arenas, M. Metabolomics Reveals Favorable Metabolic Changes in the Plasma of Breast Cancer Patients after Surgery and Adjuvant Treatment. Preprints2024, 2024081820. https://doi.org/10.20944/preprints202408.1820.v1
Jiménez-Franco, A.; Jiménez-Aguilar, J. M.; Canela-Capdevila, M.; García-Pablo, R.; Castañé, H.; Martínez-Navidad, C.; Araguas, P.; Malavé, B.; Benavides-Villarreal, R.; Acosta, J. C.; Onoiu, A. I.; Somaiah, N.; Camps, J.; Joven, J.; Arenas, M. Metabolomics Reveals Favorable Metabolic Changes in the Plasma of Breast Cancer Patients after Surgery and Adjuvant Treatment. Preprints 2024, 2024081820. https://doi.org/10.20944/preprints202408.1820.v1
Jiménez-Franco, A.; Jiménez-Aguilar, J. M.; Canela-Capdevila, M.; García-Pablo, R.; Castañé, H.; Martínez-Navidad, C.; Araguas, P.; Malavé, B.; Benavides-Villarreal, R.; Acosta, J. C.; Onoiu, A. I.; Somaiah, N.; Camps, J.; Joven, J.; Arenas, M. Metabolomics Reveals Favorable Metabolic Changes in the Plasma of Breast Cancer Patients after Surgery and Adjuvant Treatment. Preprints2024, 2024081820. https://doi.org/10.20944/preprints202408.1820.v1
APA Style
Jiménez-Franco, A., Jiménez-Aguilar, J. M., Canela-Capdevila, M., García-Pablo, R., Castañé, H., Martínez-Navidad, C., Araguas, P., Malavé, B., Benavides-Villarreal, R., Acosta, J. C., Onoiu, A. I., Somaiah, N., Camps, J., Joven, J., & Arenas, M. (2024). Metabolomics Reveals Favorable Metabolic Changes in the Plasma of Breast Cancer Patients after Surgery and Adjuvant Treatment. Preprints. https://doi.org/10.20944/preprints202408.1820.v1
Chicago/Turabian Style
Jiménez-Franco, A., Jorge Joven and Meritxell Arenas. 2024 "Metabolomics Reveals Favorable Metabolic Changes in the Plasma of Breast Cancer Patients after Surgery and Adjuvant Treatment" Preprints. https://doi.org/10.20944/preprints202408.1820.v1
Abstract
Background/Objectives: The management of early breast cancer (BC) includes surgery, followed by adjuvant radiotherapy, chemotherapy, hormone therapy, or immunotherapy. However, the influence of these interventions in metabolic reprogramming remains unknown. This study explored alterations in the plasma metabolome of BC patients following distinct treatments to deepen our understanding of BC pathophysiology, outcomes, and the identification of potential biomarkers. Methods: We included 52 women diagnosed with BC and candidates for surgery as primary oncological treatment. Blood samples were collected at diagnosis, two weeks post-surgery, and one month post-radiotherapy. Plasma samples from 49 healthy women served as controls. Targeted metabolomics assessed 74 metabolites spanning carbohydrates, amino acids, lipids, nucleotide pathways, energy metabolism, and xenobiotic biodegradation. Results: Before treatment, BC patients exhibited notable changes in carbohydrate, nucleotide, lipid, and amino acid metabolism. We noticed a gradual restoration of specific metabolite levels (hypoxanthine, 3-phosphoglyceric acid, xylonic acid, and maltose) throughout different treatments, suggesting a normalization of nucleotide and carbohydrate metabolic pathways. Moreover, we observed increased dodecanoic acid concentrations, a metabolite associated with cancer protection. These variations distinguished patients from controls with high specificity and sensitivity. Conclusion: Oncological treatments modified the metabolism of patients towards a favorable profile with a decrease in the pathways that favor cell proliferation and an increase in the levels of anticancer molecules. These findings emphasize the pivotal role of metabolomics in recognizing the biological pathways influenced by each cancer treatment and the resulting metabolic consequences. Furthermore, it aids in identifying potential biomarkers for disease onset and progression.
Keywords
breast cancer; chemotherapy; metabolism; metabolomics; radiotherapy
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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