Version 1
: Received: 25 August 2024 / Approved: 26 August 2024 / Online: 26 August 2024 (11:26:48 CEST)
How to cite:
Fernandes Silva, L.; Vangipurapu, J.; Oravilahti, A.; Laakso, M. Novel Metabolites Associated with Decreased Gfr: A 12-Year Follow-Up of the METSIM Cohort. Preprints2024, 2024081834. https://doi.org/10.20944/preprints202408.1834.v1
Fernandes Silva, L.; Vangipurapu, J.; Oravilahti, A.; Laakso, M. Novel Metabolites Associated with Decreased Gfr: A 12-Year Follow-Up of the METSIM Cohort. Preprints 2024, 2024081834. https://doi.org/10.20944/preprints202408.1834.v1
Fernandes Silva, L.; Vangipurapu, J.; Oravilahti, A.; Laakso, M. Novel Metabolites Associated with Decreased Gfr: A 12-Year Follow-Up of the METSIM Cohort. Preprints2024, 2024081834. https://doi.org/10.20944/preprints202408.1834.v1
APA Style
Fernandes Silva, L., Vangipurapu, J., Oravilahti, A., & Laakso, M. (2024). Novel Metabolites Associated with Decreased Gfr: A 12-Year Follow-Up of the METSIM Cohort. Preprints. https://doi.org/10.20944/preprints202408.1834.v1
Chicago/Turabian Style
Fernandes Silva, L., Anniina Oravilahti and Markku Laakso. 2024 "Novel Metabolites Associated with Decreased Gfr: A 12-Year Follow-Up of the METSIM Cohort" Preprints. https://doi.org/10.20944/preprints202408.1834.v1
Abstract
Identification of the individuals having impaired kidney function is essential in preventing the complications of this disease. We measured 1 009 metabolites at the baseline study in 10 159 Finnish men of the METSIM cohort and associated the metabolites with estimated glomerular filtration rate (eGFR). A total of 7 090 men participated in the 12-year follow-up study. Non-targeted metabolomics profiling was performed at Metabolon, Inc. (Morrisville, NC, USA) on EDTA plasma samples obtained after overnight fasting. We applied Liquid chromatography-mass spectrometry (LC-MS/MS) to identify the metabolites (the Metabolon DiscoveryHD4 platform). We performed association analyses between the eGFR and metabolites using linear regression adjusted for confounding factors. We found 108 metabolites significantly associated with a decrease in eGFR, and 28 of them were novel including 12 amino acids, 8 xenobiotics, 5 lipids, 1 nucleotide, 1 peptide, and 1 partially characterized molecule. The most significant associations were with five amino acids, N-acetylmethionine, N-acetylvaline, gamma-carboxyglutamate, 3-methylglutaryl-carnitine, and pro-line. We identified 28 novel metabolites associated with decreased eGFR in the 12-year follow-up study of the METSIM cohort.
Keywords
Genetics; metabolomics; type 2 diabetes; glomerular filtration rate
Subject
Medicine and Pharmacology, Internal Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
