Aponrat, P.; Detkalaya, O.; Phlongtong, N.; Eksatit, N.; Kananub, S.; Kaewmongkol, S.; Kaewmongkol, G. Predicting Catheter-Associated Urinary Tract Infections and Antibiotic Resistance in Hospitalized Dogs: Impact of Prior Antibiotic Treatment. Preprints2024, 2024081836. https://doi.org/10.20944/preprints202408.1836.v1
APA Style
Aponrat, P., Detkalaya, O., Phlongtong, N., Eksatit, N., Kananub, S., Kaewmongkol, S., & Kaewmongkol, G. (2024). Predicting Catheter-Associated Urinary Tract Infections and Antibiotic Resistance in Hospitalized Dogs: Impact of Prior Antibiotic Treatment. Preprints. https://doi.org/10.20944/preprints202408.1836.v1
Chicago/Turabian Style
Aponrat, P., Sarawan Kaewmongkol and Gunn Kaewmongkol. 2024 "Predicting Catheter-Associated Urinary Tract Infections and Antibiotic Resistance in Hospitalized Dogs: Impact of Prior Antibiotic Treatment" Preprints. https://doi.org/10.20944/preprints202408.1836.v1
Abstract
Urethral catheterization, a common procedure in canine patients, often compromises urinary tract defenses, leading to bacterial colonization and potential systemic infection. Despite posi-tive urine cultures, clinical signs of urinary tract infection (UTI) may be absent in catheterized dogs. This study evaluated the correlation between urinalysis results and catheter-associated UTIs in hospitalized dogs, considering prior antibiotic treatment and antibiotic resistance. Twen-ty-eight dogs at Kasetsart University Veterinary Teaching Hospital were included. Urine cul-tures and antibiotic sensitivity tests were performed on days 0, 3, and 7 and prior to catheter re-moval, with a positive urine culture defined at ≥104 CFU/mL. Instances of pyuria (>5 WBCs/HPF), hematuria (>5 RBCs/HPF), and bacteriuria were recorded. A statistical analysis showed no significant association between the urine culture results and urinalysis parameters, catheterization duration, breed, sex, neutering status, or age. Dogs with prior antibiotic treat-ments exhibited UTI-free periods after catheter placement that were longer than those previous-ly reported. A Kaplan–Meier analysis showed a probability of being UTI-free of 92.8% at 3 days, declining to 60.7% by 7 days and 53.6% by 10 days. Alarmingly, eighty percent of the isolates (12/15) were multidrug-resistant organisms (MDROs), resistant to ≥3 antimicrobials. Routine urinalysis cannot reliably predict catheter-associated UTI, and the high rate of MDROs under-scores the need for judicious antibiotic use and improved diagnostic tools.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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