Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome

How to cite: AKINSULIE, O. C.; Olowu, B. I.; Adesola, R. O.; Adenaya, A.; Banwo, O. G.; Ugwu, C. E.; Idris, I.; Babawale, P. I.; Akande, Q. A.; Olukogbe, O.; Shahzad, S.; Agbaje, J. M. Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome. Preprints 2024, 2024081862. https://doi.org/10.20944/preprints202408.1862.v1 AKINSULIE, O. C.; Olowu, B. I.; Adesola, R. O.; Adenaya, A.; Banwo, O. G.; Ugwu, C. E.; Idris, I.; Babawale, P. I.; Akande, Q. A.; Olukogbe, O.; Shahzad, S.; Agbaje, J. M. Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome. Preprints 2024, 2024081862. https://doi.org/10.20944/preprints202408.1862.v1

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MDPI and ACS Style

AKINSULIE, O. C.; Olowu, B. I.; Adesola, R. O.; Adenaya, A.; Banwo, O. G.; Ugwu, C. E.; Idris, I.; Babawale, P. I.; Akande, Q. A.; Olukogbe, O.; Shahzad, S.; Agbaje, J. M. Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome. Preprints 2024, 2024081862. https://doi.org/10.20944/preprints202408.1862.v1

APA Style

AKINSULIE, O. C., Olowu, B. I., Adesola, R. O., Adenaya, A., Banwo, O. G., Ugwu, C. E., Idris, I., Babawale, P. I., Akande, Q. A., Olukogbe, O., Shahzad, S., & Agbaje, J. M. (2024). Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome. Preprints. https://doi.org/10.20944/preprints202408.1862.v1

Chicago/Turabian Style

AKINSULIE, O. C., Sammuel Shahzad and Jesuferanmi Mary Agbaje. 2024 "Complex Interaction between Gut Microbiome and Autoimmunity: Focus on Antiphospholipid Syndrome" Preprints. https://doi.org/10.20944/preprints202408.1862.v1

Abstract

Antiphospholipid syndrome (APS) otherwise known as Hughes syndrome is a systemic autoimmune disease typically linked with characteristic features like thrombosis and pregnancy morbidity with the presence of antiphospholipid antibodies (aPLs). Although anticoagulation is the current flagship treatment for APS, there are reports indicating a considerable failure following this regimen in a significant number of obstetric APS and thrombotic APS cases. Antiphospholipid antibodies (aPLs) bind anionic phospholipids or protein-phospholipid complexes within the cell membrane. Here, we gave a general overview of the biology of APS and the human gut microbiome, our current understanding of the gut bacteria-immune axis in autoimmunity focus on the potential link to APS, highlighting the implicated microorganisms in this context, and proposing recommendations on future therapeutic development.

Keywords

Gut Microbiome; Antiphospholipid syndrome; Antiphospholipid antibodies; Autoimmunity; Therapeutics

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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