Version 1
: Received: 24 August 2024 / Approved: 26 August 2024 / Online: 27 August 2024 (15:29:39 CEST)
How to cite:
Cui, L.; Watanabe, S.; Miyanaga, K.; Kiga, K.; Sasahara, T.; Aiba, Y.; Tan, X.-E.; Veeranarayanan, S.; Thitiananpakorn, K.; Nguyen, H. M.; Wannigama, D. L. Comprehensive Review on Phage Therapy and Phage-Based Drug Development. Preprints2024, 2024081879. https://doi.org/10.20944/preprints202408.1879.v1
Cui, L.; Watanabe, S.; Miyanaga, K.; Kiga, K.; Sasahara, T.; Aiba, Y.; Tan, X.-E.; Veeranarayanan, S.; Thitiananpakorn, K.; Nguyen, H. M.; Wannigama, D. L. Comprehensive Review on Phage Therapy and Phage-Based Drug Development. Preprints 2024, 2024081879. https://doi.org/10.20944/preprints202408.1879.v1
Cui, L.; Watanabe, S.; Miyanaga, K.; Kiga, K.; Sasahara, T.; Aiba, Y.; Tan, X.-E.; Veeranarayanan, S.; Thitiananpakorn, K.; Nguyen, H. M.; Wannigama, D. L. Comprehensive Review on Phage Therapy and Phage-Based Drug Development. Preprints2024, 2024081879. https://doi.org/10.20944/preprints202408.1879.v1
APA Style
Cui, L., Watanabe, S., Miyanaga, K., Kiga, K., Sasahara, T., Aiba, Y., Tan, X. E., Veeranarayanan, S., Thitiananpakorn, K., Nguyen, H. M., & Wannigama, D. L. (2024). Comprehensive Review on Phage Therapy and Phage-Based Drug Development. Preprints. https://doi.org/10.20944/preprints202408.1879.v1
Chicago/Turabian Style
Cui, L., Huong Minh Nguyen and Dhammika Leshan Wannigama. 2024 "Comprehensive Review on Phage Therapy and Phage-Based Drug Development" Preprints. https://doi.org/10.20944/preprints202408.1879.v1
Abstract
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) bacteria. This comprehensive review explores the historical context, the modern resurgence of phage therapy, and phage-facilitated advancements in medical and technological fields. It details the mechanisms of action and applications of phages in treating MDR bacterial infections, particularly those associated with biofilms and intracellular pathogens. The review further highlights innovative uses of phages in vaccine development, cancer therapy, and as gene delivery vectors. Despite its targeted and efficient approach, phage therapy faces challenges related to phage stability, immune response, and regulatory approval. By examining these areas in detail, this review underscores the immense potential and remaining hurdles in integrating phage-based therapies into modern medical practices.
Medicine and Pharmacology, Complementary and Alternative Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
