Version 1
: Received: 26 August 2024 / Approved: 27 August 2024 / Online: 28 August 2024 (09:33:36 CEST)
How to cite:
Georgi, C.; Coffin, C. S.; Cooper, C. Understanding Hepatitis B Virus (HBV) Persistence: Mechanisms, Consequences and Implications for Cure. Preprints2024, 2024081996. https://doi.org/10.20944/preprints202408.1996.v1
Georgi, C.; Coffin, C. S.; Cooper, C. Understanding Hepatitis B Virus (HBV) Persistence: Mechanisms, Consequences and Implications for Cure. Preprints 2024, 2024081996. https://doi.org/10.20944/preprints202408.1996.v1
Georgi, C.; Coffin, C. S.; Cooper, C. Understanding Hepatitis B Virus (HBV) Persistence: Mechanisms, Consequences and Implications for Cure. Preprints2024, 2024081996. https://doi.org/10.20944/preprints202408.1996.v1
APA Style
Georgi, C., Coffin, C. S., & Cooper, C. (2024). Understanding Hepatitis B Virus (HBV) Persistence: Mechanisms, Consequences and Implications for Cure. Preprints. https://doi.org/10.20944/preprints202408.1996.v1
Chicago/Turabian Style
Georgi, C., Carla S. Coffin and Curtis Cooper. 2024 "Understanding Hepatitis B Virus (HBV) Persistence: Mechanisms, Consequences and Implications for Cure" Preprints. https://doi.org/10.20944/preprints202408.1996.v1
Abstract
Hepatitis B Virus (HBV) infection carries a significant health burden worldwide. It is a leading cause of acute and chronic liver disease resulting in cirrhosis and hepatocellular carcinoma (HCC). This virus affects millions globally, and despite several medical advancements, research, and efforts to develop curative treatment, the persistence of HBV in infected individuals by cccDNA and integration pose formidable challenges. This review aims to provide a broad-based overview of HBV persistence, integration and the implications for chronic infection and tumorigenesis. By considering these points, we bring forth insights into the advancement of therapies that aim to disrupt the chronicity of HBV infection and improve clinical outcomes.
Keywords
Hepatitis B infection; cccDNA; HBV DNA integration; viral persistence; chronic infection; Hepatocellular Carcinoma
Subject
Public Health and Healthcare, Primary Health Care
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
