Preprint Article Version 1 This version is not peer-reviewed

Assessment of Serum ACTH, Melatonin, and Cortisol Levels in Patients with Hormone Imbalance and Multiple Sclerosis

Version 1 : Received: 29 August 2024 / Approved: 30 August 2024 / Online: 30 August 2024 (15:45:54 CEST)

How to cite: Mohammed Mosa jassim, M. Assessment of Serum ACTH, Melatonin, and Cortisol Levels in Patients with Hormone Imbalance and Multiple Sclerosis. Preprints 2024, 2024082255. https://doi.org/10.20944/preprints202408.2255.v1 Mohammed Mosa jassim, M. Assessment of Serum ACTH, Melatonin, and Cortisol Levels in Patients with Hormone Imbalance and Multiple Sclerosis. Preprints 2024, 2024082255. https://doi.org/10.20944/preprints202408.2255.v1

Abstract

Introduction: Multiple sclerosis (MS) is a long-term inflammatory disease that affects the central nervous system due to an abnormal immune response. Hormonal and enzyme changes in these patients can influence the progression and prognosis of the disease. In this research, the levels of cortisol, adrenocorticotropic hormone (ACTH), melatonin, and lactate dehydrogenase (LDH) in the blood of MS patients were studied. Methods: This study involved 50 MS patients and 50 healthy individuals. The levels of ACTH, melatonin, and cortisol in the blood were measured using specific ELISA kits. The data obtained were then analyzed statistically using SPSS software. Results: The findings revealed a significant increase in the levels of cortisol and LDH in MS patients (P

Keywords

Multiple sclerosis; cortisol; ACTH; melatonin; inflammation; hypothalamic-pituitary-adrenal axis

Subject

Medicine and Pharmacology, Clinical Medicine

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