PreprintArticleVersion 1This version is not peer-reviewed
Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure
Version 1
: Received: 30 August 2024 / Approved: 30 August 2024 / Online: 30 August 2024 (15:32:18 CEST)
How to cite:
Ristic-Medic, D.; Takic, M.; Pokimica, B.; Terzic, B.; Kojadinovic, M.; Lepic, T.; Radjen, S.; Vucic, V. Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure. Preprints2024, 2024082264. https://doi.org/10.20944/preprints202408.2264.v1
Ristic-Medic, D.; Takic, M.; Pokimica, B.; Terzic, B.; Kojadinovic, M.; Lepic, T.; Radjen, S.; Vucic, V. Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure. Preprints 2024, 2024082264. https://doi.org/10.20944/preprints202408.2264.v1
Ristic-Medic, D.; Takic, M.; Pokimica, B.; Terzic, B.; Kojadinovic, M.; Lepic, T.; Radjen, S.; Vucic, V. Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure. Preprints2024, 2024082264. https://doi.org/10.20944/preprints202408.2264.v1
APA Style
Ristic-Medic, D., Takic, M., Pokimica, B., Terzic, B., Kojadinovic, M., Lepic, T., Radjen, S., & Vucic, V. (2024). Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure. Preprints. https://doi.org/10.20944/preprints202408.2264.v1
Chicago/Turabian Style
Ristic-Medic, D., Slavica Radjen and Vesna Vucic. 2024 "Dietary Omega-3 PUFA Intake in Patients with Chronic Kidney Disease: The Association with Vitamin D Deficiency, Intima-Media Thickness and Blood Pressure" Preprints. https://doi.org/10.20944/preprints202408.2264.v1
Abstract
Background/Objectives: Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular disease (CVD). Carotid intima-media thickness (C-IMT) is a non-invasive marker of atherosclerosis. Low omega-3 polyunsaturated fatty acids (PUFA) intake and vitamin D deficiency are potential cardiometabolic risk factors in patients with CKD. The aim of this study was to evaluate dietary intake and status of omega-3 PUFA and vitamin D in pre-dialysis and hemodialysis patients and to examine the link of dietary α-linolenic acid (ALA) and fish consumption with blood pressure and C-IMT in CKD patients. Methods: All 77 selected patients (36 pre-dialysis, 41 on hemodialysis) underwent standardized clinical, nutritional, and laboratory assessments. Repeated 24-hour recalls were performed to assess dietary intake. The fatty acid profile was determined by gas-liquid chromatography. Results: Inadequate vitamin D intake and vitamin D status were found in 95% of patients. PUFAs profiles did not differ between hemodialysis and pre-dialysis participants. Dietary intake of ALA was negatively correlated with systolic blood pressure (SBP) (p=0.007), C-IMT (p=0.002), serum CRP (p=0.044), iPTH (p=0.01) and 25(OH)D3 (p=0.006). ALA intake of more than 0.23 g/daily was associated with lower SBP (p=0.001), serum 25(OH)D3 (p=0.004), and C-IMT (p=0.002). Conclusions: This study contributes to a better understanding of the relationship between dietary ALA intake and C-IMT in CKD. The results of this study could emphasize the significant role of the high prevalence of vitamin D deficiency and inadequate omega-3 PUFA intake and status considering CVD health in CKD patients.
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
