Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Validation of Greulich and Pyle Atlas for Radiological Bone Age Assessment in Pediatric Population from the Canary Islands

Isidro Miguel Martín Pérez
* ORCID logo ,
Sebastián Eustaquio Martín Pérez
,
Jesús María Vega González
,
Ruth Molina Suárez
,
Alfonso Miguel García Hernández
,
Fidel Rodríguez Hernández
,
Mario Herrera Perez
Version 1 : Received: 31 August 2024 / Approved: 2 September 2024 / Online: 2 September 2024 (10:49:48 CEST)

How to cite: Martín Pérez, I. M.; Martín Pérez, S. E.; Vega González, J. M.; Molina Suárez, R.; García Hernández, A. M.; Rodríguez Hernández, F.; Herrera Perez, M. Validation of Greulich and Pyle Atlas for Radiological Bone Age Assessment in Pediatric Population from the Canary Islands. Preprints 2024, 2024090071. https://doi.org/10.20944/preprints202409.0071.v1 Martín Pérez, I. M.; Martín Pérez, S. E.; Vega González, J. M.; Molina Suárez, R.; García Hernández, A. M.; Rodríguez Hernández, F.; Herrera Perez, M. Validation of Greulich and Pyle Atlas for Radiological Bone Age Assessment in Pediatric Population from the Canary Islands. Preprints 2024, 2024090071. https://doi.org/10.20944/preprints202409.0071.v1

Abstract

Accurate assessment of bone age (BA) is crucial for pediatric clinical practice. This study validated the Radiological Reference Atlas for Bone Age in the Canary Islands Population with a total of 203 anteroposterior left hand and wrist radiographs from healthy children (91 females, 112 males) across preschool, school-age, and adolescent stages. Intra-observer agreement, assessed by intraclass correlation coefficients (BAA1: ICC = 1.000, BAA2: ICC = 0.995, BAA3: ICC = 0.943), showed differing levels of precision among assessors. Inter-observer agreement was high (Pearson’s r = 0.905 - 0.951), suggesting consistent evaluations across different expertise levels. Accuracy analysis revealed significant BA underestimation compared to chronological age (CA) in preschool (MD = -17.036 months, p < 0.001) and school-age (MD = -8.165 months, p < 0.001) groups, but closer agreement in teenagers (MD = -0.33 months, p = 0.550). Furthermore, a relevant underestimation in the teenage stage for girls compared to boys was also noted. These findings underscore the atlas's precision; however, its accuracy for BA assessment in younger children and adolescent girls needs to be approached with caution.

Keywords

diagnostic imaging; radiography; age determination by skeleton; children; Greulich and Pyle Atlas; Canary Islands

Subject

Medicine and Pharmacology, Pediatrics, Perinatology and Child Health

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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