Docking Analysis on Mutated Proteins in Cardio-Facio-Cutaneous Syndrome: Amentoflavone E Hypericin Potential Role

Ivan ferrari

doi:10.20944/preprints202409.0140.v1

Preprint Article Version 1 This version is not peer-reviewed

Version 1 : Received: 1 September 2024 / Approved: 2 September 2024 / Online: 3 September 2024 (11:32:29 CEST)

Cardiofaciocutaneous (CFC) syndrome, linked to mutations in genes including KRAS, BRAF, MEK1, and MEK2, leads to dysregulated RAS-MAPK signaling with limited therapeutic options. This study utilized molecular docking simulations to screen natural compounds against mutated KRAS, BRAF, MEK1, and MEK2 structures. Promising candidates such as Amentoflavone and Hypericin displayed strong binding affinities and favorable interactions with mutated sites, suggesting their potential as lead molecules for targeted therapies in CFC syndrome. This research offers novel insights into therapeutic interventions for this rare genetic disorder.

Hypericin; Amentoflavone; Docking analysis; Autodock Vina; Cardiofaciocutaneous

Biology and Life Sciences, Immunology and Microbiology

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Docking Analysis on Mutated Proteins in Cardio-Facio-Cutaneous Syndrome: Amentoflavone E Hypericin Potential Role

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