Version 1
: Received: 1 September 2024 / Approved: 2 September 2024 / Online: 3 September 2024 (11:21:27 CEST)
How to cite:
Xodo, S.; Benchick, B.; Battello, G.; Baccarini, G.; Angelini, M.; Orsaria, M.; Driul, L. Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report. Preprints2024, 2024090141. https://doi.org/10.20944/preprints202409.0141.v1
Xodo, S.; Benchick, B.; Battello, G.; Baccarini, G.; Angelini, M.; Orsaria, M.; Driul, L. Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report. Preprints 2024, 2024090141. https://doi.org/10.20944/preprints202409.0141.v1
Xodo, S.; Benchick, B.; Battello, G.; Baccarini, G.; Angelini, M.; Orsaria, M.; Driul, L. Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report. Preprints2024, 2024090141. https://doi.org/10.20944/preprints202409.0141.v1
APA Style
Xodo, S., Benchick, B., Battello, G., Baccarini, G., Angelini, M., Orsaria, M., & Driul, L. (2024). Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report. Preprints. https://doi.org/10.20944/preprints202409.0141.v1
Chicago/Turabian Style
Xodo, S., Maria Orsaria and Lorenza Driul. 2024 "Successful Resolution of Cervical Insufficiency after Administration of a Novel Triple Antibiotic Therapy: A Case Report" Preprints. https://doi.org/10.20944/preprints202409.0141.v1
Abstract
Background
Cervical insufficiency, marked by recurrent painless cervix dilation leading to second-trimester pregnancy losses, is traditionally managed through cerclage placement and vaginal progesterone administration. However, a recent experimental approach targeted intra-amniotic inflammation or infection in a selected group of women with cervical dilation over 1 cm, intact membranes, and no uterine contractions in the second or third trimester.
Case presentation
We report a case of a 21 year old primigravid woman who experienced resolution of mid-trimester cervical insufficiency after the administration of triple antibiotic therapy, as confirmed by ultrasound monitoring. Remarkably, the patient successfully carried the pregnancy to term and delivered a healthy baby.
Conclusions
This case highlights the potential effectiveness of a novel combination of antibiotics, even in the presence of several high-risk pregnancy conditions, and underscores the possibility of a favorable outcome.
Keywords
Cervical insufficiency; triple antibiotic therapy; cerclage; intra-amniotic infection; case report
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
