One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study

Marta Bassi; Marina Francesca Strati; Gaia Spiandorello; Marta Scalas; Federico Cresta; Maria Grazia Calevo; Giuseppe D'Annunzio; Carlo Castellani; Nicola Minuto; Mohamad Maghnie; Rosaria Casciaro

doi:10.20944/preprints202409.0206.v1

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preprints.org > medicine and pharmacology > clinical medicine > doi: 10.20944/preprints202409.0206.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study

Marta Bassi

Marina Francesca Strati

^* ,

Version 1 : Received: 2 September 2024 / Approved: 3 September 2024 / Online: 4 September 2024 (04:52:09 CEST)

How to cite: Bassi, M.; Strati, M. F.; Spiandorello, G.; Scalas, M.; Cresta, F.; Calevo, M. G.; D'Annunzio, G.; Castellani, C.; Minuto, N.; Maghnie, M.; Casciaro, R. One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study. Preprints 2024, 2024090206. https://doi.org/10.20944/preprints202409.0206.v1 Bassi, M.; Strati, M. F.; Spiandorello, G.; Scalas, M.; Cresta, F.; Calevo, M. G.; D'Annunzio, G.; Castellani, C.; Minuto, N.; Maghnie, M.; Casciaro, R. One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study. Preprints 2024, 2024090206. https://doi.org/10.20944/preprints202409.0206.v1

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MDPI and ACS Style

Bassi, M.; Strati, M. F.; Spiandorello, G.; Scalas, M.; Cresta, F.; Calevo, M. G.; D'Annunzio, G.; Castellani, C.; Minuto, N.; Maghnie, M.; Casciaro, R. One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study. Preprints 2024, 2024090206. https://doi.org/10.20944/preprints202409.0206.v1

APA Style

Bassi, M., Strati, M. F., Spiandorello, G., Scalas, M., Cresta, F., Calevo, M. G., D'Annunzio, G., Castellani, C., Minuto, N., Maghnie, M., & Casciaro, R. (2024). One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study. Preprints. https://doi.org/10.20944/preprints202409.0206.v1

Chicago/Turabian Style

Bassi, M., Mohamad Maghnie and Rosaria Casciaro. 2024 "One-Year Effect of Elexacaftor/Tezacaftor/Ivacaftor Therapy on HbA1c Levels and Insulin Requirement in Patients with Insulin-Dependent Cystic Fibrosis-Related Diabetes: A Retrospective Observational Study" Preprints. https://doi.org/10.20944/preprints202409.0206.v1

Abstract

The main objective is to evaluate HbA1c levels in patients with cystic fibrosis-related diabetes (CFRD) after one-year of therapy with elexacaftor/tezacaftor/ivacaftor (ETI). The secondary objective is to study the changes in total daily insulin dose (TDD), pulmonary function and metabolism in this population. A retrospective sin gle-center observational study was conducted at Regional Cystic Fibrosis Centre and Diabetology Centre of IRCCS Istituto Giannina Gaslini. The observation period was divided into Time 0 (ETI treatment initiation), Time 1 (T1 – 3 months of ETI therapy), Time 2 (T2 - 6 months of therapy) and Time 3 (T3 - 12 months of therapy). Demographic and clinical data were collected. The results were then stratified by genotype (F508del in homozygosity or heterozygosity). Twenty-eight patients with CFRD undergoing insulin therapy were included. TDD (IU) significantly decreased at T1 and T2, but not at T3, as for HbA1c. The number of hospitalizations and pulmonary exacerbations decreased significantly. We demonstrated both improvement in glycemic control (by means of HbA1c) and insulin requirement in insulin dependent CFRD patients after one year of only ETI treatment.

Keywords

CFRD; cystic fibrosis; diabetes; CFTR modulators; ETI treatment

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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