Version 1
: Received: 3 September 2024 / Approved: 3 September 2024 / Online: 3 September 2024 (18:08:12 CEST)
How to cite:
Ong, Y. C.; Tejo, B. A.; Yap, W. B. An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses. Preprints2024, 2024090239. https://doi.org/10.20944/preprints202409.0239.v1
Ong, Y. C.; Tejo, B. A.; Yap, W. B. An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses. Preprints 2024, 2024090239. https://doi.org/10.20944/preprints202409.0239.v1
Ong, Y. C.; Tejo, B. A.; Yap, W. B. An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses. Preprints2024, 2024090239. https://doi.org/10.20944/preprints202409.0239.v1
APA Style
Ong, Y. C., Tejo, B. A., & Yap, W. B. (2024). An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses. Preprints. https://doi.org/10.20944/preprints202409.0239.v1
Chicago/Turabian Style
Ong, Y. C., Bimo Ario Tejo and Wei Boon Yap. 2024 "An Immunoinformatics Approach for Identifying and Designing Conserved Multi-Epitope Vaccines for Coronaviruses" Preprints. https://doi.org/10.20944/preprints202409.0239.v1
Abstract
The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has exposed the vulnerabilities and unpreparedness of the global healthcare system in dealing with emerging zoonoses. In the past two decades, coronaviruses (CoV) have been responsible for three major viral outbreaks, and the likelihood of future outbreaks caused by these viruses is high and nearly inevitable. Therefore, effective prophylactic universal vaccines targeting multiple circulating and emerging coronavirus strains are warranted. This study utilized an immunoinformatic approach to identify evolutionarily conserved CD4+ (HTL) and CD8+ (CTL) T cells, and B-cell epitopes in the coronaviral spike (S) glycoprotein. A total of 132 epitopes were identified, with the majority of them found conserved in the bat CoV, pangolins CoV, endemic coronaviruses, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV). Their peptide sequences were then aligned and assembled to identify the overlapping regions. Eventually, two major peptide assemblies were derived based on their promising immune-stimulating properties. In this light, they can serve as lead candidates for universal coronavirus vaccine development, particularly in the search for pan-coronavirus multi-epitope universal vaccines that can confer protection against current and novel coronaviruses.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
