Version 1
: Received: 4 September 2024 / Approved: 5 September 2024 / Online: 5 September 2024 (12:40:28 CEST)
How to cite:
Kaplan, B.; von Dannecker, R.; Arbiser, J. Carcinogenesis of the Human Scalp. An Immunometabolic Centered View. Preprints2024, 2024090450. https://doi.org/10.20944/preprints202409.0450.v1
Kaplan, B.; von Dannecker, R.; Arbiser, J. Carcinogenesis of the Human Scalp. An Immunometabolic Centered View. Preprints 2024, 2024090450. https://doi.org/10.20944/preprints202409.0450.v1
Kaplan, B.; von Dannecker, R.; Arbiser, J. Carcinogenesis of the Human Scalp. An Immunometabolic Centered View. Preprints2024, 2024090450. https://doi.org/10.20944/preprints202409.0450.v1
APA Style
Kaplan, B., von Dannecker, R., & Arbiser, J. (2024). Carcinogenesis of the Human Scalp. An Immunometabolic Centered View. Preprints. https://doi.org/10.20944/preprints202409.0450.v1
Chicago/Turabian Style
Kaplan, B., Rebecca von Dannecker and Jack Arbiser. 2024 "Carcinogenesis of the Human Scalp. An Immunometabolic Centered View" Preprints. https://doi.org/10.20944/preprints202409.0450.v1
Abstract
The human scalp is a common site of skin cancer in humans, with non-melanoma skin cancer being exceedingly common. In this review, two dermatologists with extensive experience in cutaneous oncology will discuss unique features of the epidemiology of cancer of the scalp. Clinical observations on these common skin cancers lead to insight into the pathogenesis and potential prevention and treatment of cutaneous scalp neoplasia. Our hypothesis is that the presence of hair protects against the development of skin cancer, but not by serving as a physical shield, but rather by providing a continuous IL-17 biased immunosurveillance. Loss of hair allow release from immunosurveillance, resulting in expansion of neoplastic cells towards skin cancer. Both hair follicles and metabolic changes in stroma allow permissiveness for tumor promotion.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
