Version 1
: Received: 5 September 2024 / Approved: 5 September 2024 / Online: 6 September 2024 (08:12:07 CEST)
How to cite:
Pilotzi Xahuentitla, H.; Ortega Montes, J. G.; Gnecco Medina, D. H.; Terán Vazquez, J. L.; Hernández Núñez, E.; Orea Flores, M. L. Synthesis of methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates. Preprints2024, 2024090483. https://doi.org/10.20944/preprints202409.0483.v1
Pilotzi Xahuentitla, H.; Ortega Montes, J. G.; Gnecco Medina, D. H.; Terán Vazquez, J. L.; Hernández Núñez, E.; Orea Flores, M. L. Synthesis of methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates. Preprints 2024, 2024090483. https://doi.org/10.20944/preprints202409.0483.v1
Pilotzi Xahuentitla, H.; Ortega Montes, J. G.; Gnecco Medina, D. H.; Terán Vazquez, J. L.; Hernández Núñez, E.; Orea Flores, M. L. Synthesis of methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates. Preprints2024, 2024090483. https://doi.org/10.20944/preprints202409.0483.v1
APA Style
Pilotzi Xahuentitla, H., Ortega Montes, J. G., Gnecco Medina, D. H., Terán Vazquez, J. L., Hernández Núñez, E., & Orea Flores, M. L. (2024). Synthesis of methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates. Preprints. https://doi.org/10.20944/preprints202409.0483.v1
Chicago/Turabian Style
Pilotzi Xahuentitla, H., Emanuel Hernández Núñez and Maria Laura Orea Flores. 2024 "Synthesis of methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates" Preprints. https://doi.org/10.20944/preprints202409.0483.v1
Abstract
Chiral oxazolidine moiety is an important core in asymmetric synthesis due to its ability to participate in various stereoselective chemical reactions and because forms a part of more complex important active compounds. Therefore, in this letter we report a convenient diastereoselective and practical strategy for the synthesis of chiral methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates starting from (R)-(–)-2-phenylglycinol and methyl propiolate which were obtained via simple two chemical and stereoselective reactions.
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
