Version 1
: Received: 5 September 2024 / Approved: 6 September 2024 / Online: 6 September 2024 (03:41:04 CEST)
How to cite:
Arzik, Y.; Kizilaslan, M.; Behrem, S.; Piel, L. M. W.; White, S. N.; Çınar, M. U. Exploring Genetic Factors Associated with Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach. Preprints2024, 2024090494. https://doi.org/10.20944/preprints202409.0494.v1
Arzik, Y.; Kizilaslan, M.; Behrem, S.; Piel, L. M. W.; White, S. N.; Çınar, M. U. Exploring Genetic Factors Associated with Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach. Preprints 2024, 2024090494. https://doi.org/10.20944/preprints202409.0494.v1
Arzik, Y.; Kizilaslan, M.; Behrem, S.; Piel, L. M. W.; White, S. N.; Çınar, M. U. Exploring Genetic Factors Associated with Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach. Preprints2024, 2024090494. https://doi.org/10.20944/preprints202409.0494.v1
APA Style
Arzik, Y., Kizilaslan, M., Behrem, S., Piel, L. M. W., White, S. N., & Çınar, M. U. (2024). Exploring Genetic Factors Associated with Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach. Preprints. https://doi.org/10.20944/preprints202409.0494.v1
Chicago/Turabian Style
Arzik, Y., Stephen N. White and Mehmet Ulaş Çınar. 2024 "Exploring Genetic Factors Associated with Tapeworm Resistance in Central Anatolian Merino Sheep via GWAS Approach" Preprints. https://doi.org/10.20944/preprints202409.0494.v1
Abstract
Gastrointestinal parasite (GIP) infections pose significant challenges in pasture-based sheep farming, leading to economic losses and welfare concerns. This study aimed to uncover the ge-netic basis of resistance to tapeworm (Monezia spp.) infections in Central Anatolian Merino (CAM) sheep and explore the immunogenetic mechanisms underlying this resistance. Ge-nome-wide association studies (GWAS) were conducted between tapeworm egg burden and ge-nomic data from 227 CAM lambs. Thirteen significant SNPs were identified, with five surpassing the genome-wide threshold and eight exceeding the chromosome-wide threshold. Functional annotation revealed associations with genes involved in immune function, notably CD79A and MAP3K7. CD79A, integral to B-cell activation and antibody production, plays a key role in the immune response against parasitic infections. Its interaction with helminth-derived proteins modulates B-cell function, highlighting its potential as a therapeutic target. MAP3K7, a central regulator of immune signaling pathways, modulates host responses to helminth infections by influencing NF-κB activity. Additionally, it regulates macrophage function in bacterial infec-tions, showcasing its versatility in mediating immune responses against diverse pathogens. From a practical perspective, the findings of the current research underscore the potential of in-tegrating genomic information into breeding programs to bolster disease resilience in livestock populations for sustainable production purposes. However, further research is needed to eluci-date the functional significance of identified SNPs and associated genes. Functional studies and multi-omic approaches may provide a comprehensive understanding of host-parasite interac-tions. This study underscores the potential of genomic approaches in combating parasitic dis-eases and promoting sustainable agriculture in sheep production systems.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
