Version 1
: Received: 5 September 2024 / Approved: 6 September 2024 / Online: 6 September 2024 (13:21:23 CEST)
How to cite:
Weissberger, D.; Stenzel, M.; Hunter, L. Precious Cargo: The Role of Polymeric Nanoparticles in the Delivery of Covalent Drugs. Preprints2024, 2024090530. https://doi.org/10.20944/preprints202409.0530.v1
Weissberger, D.; Stenzel, M.; Hunter, L. Precious Cargo: The Role of Polymeric Nanoparticles in the Delivery of Covalent Drugs. Preprints 2024, 2024090530. https://doi.org/10.20944/preprints202409.0530.v1
Weissberger, D.; Stenzel, M.; Hunter, L. Precious Cargo: The Role of Polymeric Nanoparticles in the Delivery of Covalent Drugs. Preprints2024, 2024090530. https://doi.org/10.20944/preprints202409.0530.v1
APA Style
Weissberger, D., Stenzel, M., & Hunter, L. (2024). Precious Cargo: The Role of Polymeric Nanoparticles in the Delivery of Covalent Drugs. Preprints. https://doi.org/10.20944/preprints202409.0530.v1
Chicago/Turabian Style
Weissberger, D., Martina Stenzel and Luke Hunter. 2024 "Precious Cargo: The Role of Polymeric Nanoparticles in the Delivery of Covalent Drugs" Preprints. https://doi.org/10.20944/preprints202409.0530.v1
Abstract
Covalent drugs can offer significant advantages over noncovalent drugs, in terms of pharmacodynamics (i.e. target-binding properties). However, the development of covalent drugs is sometimes hampered by pharmacokinetic limitations (e.g. low bioavailability, rapid metabolism, and toxicity due to off-target binding). Polymeric nanoparticles offer a potential solution to these limitations. Delivering covalent drugs via polymeric nanoparticles provides myriad benefits in terms of drug solubility; permeability; lifetime; selectivity; controlled release; and the opportunity for synergistic administration alongside other drugs. In this short review, we examine each of these benefits in turn, illustrated through multiple case-studies.
Keywords
targeted covalent inhibitors; reactive drugs; electrophilic warheads; drug delivery; nanomedicine
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
