Version 1
: Received: 6 September 2024 / Approved: 6 September 2024 / Online: 9 September 2024 (08:02:58 CEST)
How to cite:
Tenero, L.; Piazza, M.; Sandri, M.; Ferrante, G.; Giacomello, E.; Ficial, B.; Zaffanello, M.; Biban, P.; Piacentini, G. Early Diagnosis of Bronchopulmonary Dysplasia with E-Nose: A Pilot Study in Preterm Infants. Preprints2024, 2024090579. https://doi.org/10.20944/preprints202409.0579.v1
Tenero, L.; Piazza, M.; Sandri, M.; Ferrante, G.; Giacomello, E.; Ficial, B.; Zaffanello, M.; Biban, P.; Piacentini, G. Early Diagnosis of Bronchopulmonary Dysplasia with E-Nose: A Pilot Study in Preterm Infants. Preprints 2024, 2024090579. https://doi.org/10.20944/preprints202409.0579.v1
Tenero, L.; Piazza, M.; Sandri, M.; Ferrante, G.; Giacomello, E.; Ficial, B.; Zaffanello, M.; Biban, P.; Piacentini, G. Early Diagnosis of Bronchopulmonary Dysplasia with E-Nose: A Pilot Study in Preterm Infants. Preprints2024, 2024090579. https://doi.org/10.20944/preprints202409.0579.v1
APA Style
Tenero, L., Piazza, M., Sandri, M., Ferrante, G., Giacomello, E., Ficial, B., Zaffanello, M., Biban, P., & Piacentini, G. (2024). Early Diagnosis of Bronchopulmonary Dysplasia with E-Nose: A Pilot Study in Preterm Infants. Preprints. https://doi.org/10.20944/preprints202409.0579.v1
Chicago/Turabian Style
Tenero, L., Paolo Biban and Giorgio Piacentini. 2024 "Early Diagnosis of Bronchopulmonary Dysplasia with E-Nose: A Pilot Study in Preterm Infants" Preprints. https://doi.org/10.20944/preprints202409.0579.v1
Abstract
Background: Bronchopulmonary dysplasia (BPD) is the most common respiratory disease in pre-term and is still associated with increased mortality and morbidity. The great interest lies in iden-tifying early biomarkers that can predict the development of BPD.
Objectives: This pilot study explores the potential of e-nose for early identification of BPD risk in premature infants by analyzing volatile organic compounds (VOCs) in the exhaled breath con-densate (EBC).
Materials and Methods: Fourteen mechanically ventilated very preterm infants were included in the study. Clinical parameters and EBC were collected within the first 24 hours of life. The dis-criminative ability of breath-prints between preterms who did and did not develop BPD was in-vestigated by pattern recognition, machine learning algorithm, and standard statistical methods.
Results: We found that e-nose probes can significantly predict the outcome of “no-BPD” vs “BPD”. Specifically, a subset of probes (S18, S24, S14, and S6) were found to be significantly predictive, with an AUC of 0.87, 0.89, 0.82, 0.8 and p=0.019, 0.009, 0.043, 0.047, respectively.
Conclusion: The E-nose is an easy-to-use, handheld, non-invasive electronic device that quickly samples breath. Our preliminary study has shown that it has the potential for early prediction of BPD in preterms.
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.