Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes

Version 1 : Received: 6 September 2024 / Approved: 9 September 2024 / Online: 9 September 2024 (12:27:03 CEST)

How to cite: Wendt, R.; Sobhani, A.; Diefenhardt, P.; Trappe, M.; Völker, L. A. An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes. Preprints 2024, 2024090619. https://doi.org/10.20944/preprints202409.0619.v1 Wendt, R.; Sobhani, A.; Diefenhardt, P.; Trappe, M.; Völker, L. A. An Updated Comprehensive Review on Diseases Associated with Nephrotic Syndromes. Preprints 2024, 2024090619. https://doi.org/10.20944/preprints202409.0619.v1

Abstract

There have been exciting advances in our knowledge of primary glomerular diseases and nephrotic syndromes in recent years. Beyond the histological pattern from renal biopsy, more precise phenotyping of the diseases and the use of modern nephrogenetic helps to improve treatment decisions and sometimes also to avoid unnecessary exposure to potentially toxic immunosuppression. New Biomarkers led to easier and more accurate diagnoses and more targeted therapeutic decisions. The treatment landscape is getting wider with a pipeline of promising new therapeutic agents with more sophisticated approaches. This review focuses on all aspects of entities that are associated with nephrotic syndromes with updated information on recent advances in each field. This includes podocytopathies (Focal Segmental Glomerulosclerosis and Minimal-Change Disease), Membranous Nephropathy, Membranoproliferative Glomerulonephritis, IgA-Nephropathy, Fibrillary Glomerulonephritis, Amyloidosis and monoclonal gammopathy of renal significance in the context of the nephrotic syndrome, but also renal involvement in systemic diseases, diabetic nephropathy, and drugs that are associated with nephrotic syndromes.

Keywords

nephrotic syndrome; Minimal Change disease; FSGS; membranous nephropathy; MGRS; IgAN; DKD; MPGN; edema; proteinuria; PLA2R; Nephrin

Subject

Medicine and Pharmacology, Urology and Nephrology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.