Version 1
: Received: 8 September 2024 / Approved: 9 September 2024 / Online: 9 September 2024 (09:20:55 CEST)
How to cite:
Kravchuk, E.; Trifonova, E.; Sokolova, O. S. Conformational Mobility of Voltage-Gated Ion Channels. Preprints2024, 2024090642. https://doi.org/10.20944/preprints202409.0642.v1
Kravchuk, E.; Trifonova, E.; Sokolova, O. S. Conformational Mobility of Voltage-Gated Ion Channels. Preprints 2024, 2024090642. https://doi.org/10.20944/preprints202409.0642.v1
Kravchuk, E.; Trifonova, E.; Sokolova, O. S. Conformational Mobility of Voltage-Gated Ion Channels. Preprints2024, 2024090642. https://doi.org/10.20944/preprints202409.0642.v1
APA Style
Kravchuk, E., Trifonova, E., & Sokolova, O. S. (2024). Conformational Mobility of Voltage-Gated Ion Channels. Preprints. https://doi.org/10.20944/preprints202409.0642.v1
Chicago/Turabian Style
Kravchuk, E., Elizaveta Trifonova and Olga S. Sokolova. 2024 "Conformational Mobility of Voltage-Gated Ion Channels" Preprints. https://doi.org/10.20944/preprints202409.0642.v1
Abstract
Structural biology has a strong interest in ion channels, a diverse group of membrane proteins. This group has long remained difficult to study, but much progress has been made in recent decades with improvements in biochemical methods and computational procedures. Voltage-gated ion channels undergo conformational changes upon functioning, and multiple models of activation mechanisms were proposed based on experimental data. This review focuses on the structural studies of the functioning of voltage-gated ion channels, which are accompanied by conformational changes in proteins, and the methodological advances that allow their observation. Modern experimental methods that allow obtaining ion channel proteins in specific functional states are discussed, including cryoelectron microscopy and cryoelectron tomography. Finally, new algorithms for studying the conformational mobility of proteins have been developed, which help to better understand the mechanisms of ion channel domain movements.
Keywords
voltage-gated ion channels; conformation; membrane mimetics; cryoelectron microscopy; in situ analysis; coordinated motion
Subject
Biology and Life Sciences, Biophysics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
