Preprint Article Version 1 This version is not peer-reviewed

Comparative Evaluation of the Chemical Components and Anti-inflammatory Potential of Yellow- and Blue-Flowered Meconopsis Species: M. integrifolia and M. betonicifoliaCitation: To Be Added by Editorial Staff during Production

Peizhao Cheng
,
Ruixi Gan
,
Cong Wang
,
Qian Xu
,
Kelsang Norbu
,
Feng Zhou
,
Sixin Kong
,
Zhuoma Jia
,
Dawa Jiabu
,
Xin Feng
* ,
Junsong Wang
*
Version 1 : Received: 9 September 2024 / Approved: 9 September 2024 / Online: 9 September 2024 (11:51:56 CEST)

How to cite: Cheng, P.; Gan, R.; Wang, C.; Xu, Q.; Norbu, K.; Zhou, F.; Kong, S.; Jia, Z.; Jiabu, D.; Feng, X.; Wang, J. Comparative Evaluation of the Chemical Components and Anti-inflammatory Potential of Yellow- and Blue-Flowered Meconopsis Species: M. integrifolia and M. betonicifoliaCitation: To Be Added by Editorial Staff during Production. Preprints 2024, 2024090683. https://doi.org/10.20944/preprints202409.0683.v1 Cheng, P.; Gan, R.; Wang, C.; Xu, Q.; Norbu, K.; Zhou, F.; Kong, S.; Jia, Z.; Jiabu, D.; Feng, X.; Wang, J. Comparative Evaluation of the Chemical Components and Anti-inflammatory Potential of Yellow- and Blue-Flowered Meconopsis Species: M. integrifolia and M. betonicifoliaCitation: To Be Added by Editorial Staff during Production. Preprints 2024, 2024090683. https://doi.org/10.20944/preprints202409.0683.v1

Abstract

Background/Objectives: Meconopsis has long been used in traditional Tibetan medicine to treat various diseases. However, blue-flowered Meconopsis (M. betonicifolia) is becoming increasingly scarce due to overharvesting. As a potential alternative, yellow-flowered Meconopsis (M. integrifolia) shows promise but requires comprehensive characterization. This study aimed to evaluate and compare the anti-inflammatory potential of yellow- and blue-flowered Meconopsis species. Methods: LC-MS was used to analyze the chemical profiles of yellow- and blue-flowered Meconopsis. Putative targets of shared constituents were subjected to GO and disease enrichment analysis. The LPS-induced RAW264.7 macrophage model was employed to assess anti-inflammatory effects. Metabolomics was applied to gain mechanistic insights. Results: LC-MS revealed over 70% chemical similarity between species. Enrichment analysis associated targets with inflammation-related pathways. In macrophage assays, both species demonstrated dose-dependent anti-oxidative and anti-inflammatory activities, with yellow Meconopsis exhibiting superior efficacy. Metabolomics showed modulation of key inflammatory metabolic pathways. Conclusions: This integrative study validated yellow-flowered Meconopsis as a credible alternative to its blue-flowered counterpart for anti-inflammatory applications. Metabolic profiling provided initial clues regarding their multi-targeted modes of action, highlighting clinical relevance and potential for sustainable utilization and biodiversity conservation.

Keywords

Meconopsis; Meconopsis integrifolia; Meconopsis betonicifolia; Anti-inflammation; Metabolomics; Traditional Tibetan medicine; Chemical composition

Subject

Biology and Life Sciences, Plant Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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