Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders

How to cite: Moretti, M. C.; Bonfitto, I.; Nieddu, L.; Leccisotti, I.; Dimalta, S.; Moniello, G.; Lozupone, M.; Bellomo, A.; Panza, F.; Avolio, C.; Altamura, M. Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders. Preprints 2024, 2024090714. https://doi.org/10.20944/preprints202409.0714.v1 Moretti, M. C.; Bonfitto, I.; Nieddu, L.; Leccisotti, I.; Dimalta, S.; Moniello, G.; Lozupone, M.; Bellomo, A.; Panza, F.; Avolio, C.; Altamura, M. Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders. Preprints 2024, 2024090714. https://doi.org/10.20944/preprints202409.0714.v1

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MDPI and ACS Style

Moretti, M. C.; Bonfitto, I.; Nieddu, L.; Leccisotti, I.; Dimalta, S.; Moniello, G.; Lozupone, M.; Bellomo, A.; Panza, F.; Avolio, C.; Altamura, M. Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders. Preprints 2024, 2024090714. https://doi.org/10.20944/preprints202409.0714.v1

APA Style

Moretti, M. C., Bonfitto, I., Nieddu, L., Leccisotti, I., Dimalta, S., Moniello, G., Lozupone, M., Bellomo, A., Panza, F., Avolio, C., & Altamura, M. (2024). Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders. Preprints. https://doi.org/10.20944/preprints202409.0714.v1

Chicago/Turabian Style

Moretti, M. C., Carlo Avolio and Mario Altamura. 2024 "Association of Loneliness with Functional and Cognitive Status in Minor and Major Neurocognitive Disorders" Preprints. https://doi.org/10.20944/preprints202409.0714.v1

Abstract

Background: Neurocognitive disorders (NCDs) have a variable decline in cognitive function, while loneliness was associated with cognitive impairment and increased dementia risk. In the present study, we examined the associations of loneliness with functional and cognitive status in patients with minor (mild cognitive impairment) and major NCDs (dementia). Methods: We diagnosed mild NCD (n=42) and major NCD (n=164) through DSM-5 criteria on 206 participants aged>65 years using the UCLA 3-Item Loneliness Scale (UCLA-3) to evaluate loneliness, the activities of daily living (ADL) and the instrumental activities of daily living (IADL) scales to measure functional status, and Mini-Mental State Examination (MMSE) to assess cognitive functions. Results: In a multivariate regression model, the effect of loneliness on cognitive functions was negative in major (=-1.05-p

Keywords

loneliness; mild cognitive impairment; dementia; Alzheimer’s disease; MMSE; ADL; IADL; depression; multimorbidity

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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