Version 1
: Received: 11 September 2024 / Approved: 12 September 2024 / Online: 13 September 2024 (04:17:59 CEST)
How to cite:
Vij, P.; Hussain, M. S.; Satapathy, S. K.; Cobos, E.; Tripathi, M. K. The Emerging Role of Long Noncoding RNAs’ in Sorafenib Resistance within Hepatocellular Carcinoma. Preprints2024, 2024090951. https://doi.org/10.20944/preprints202409.0951.v1
Vij, P.; Hussain, M. S.; Satapathy, S. K.; Cobos, E.; Tripathi, M. K. The Emerging Role of Long Noncoding RNAs’ in Sorafenib Resistance within Hepatocellular Carcinoma. Preprints 2024, 2024090951. https://doi.org/10.20944/preprints202409.0951.v1
Vij, P.; Hussain, M. S.; Satapathy, S. K.; Cobos, E.; Tripathi, M. K. The Emerging Role of Long Noncoding RNAs’ in Sorafenib Resistance within Hepatocellular Carcinoma. Preprints2024, 2024090951. https://doi.org/10.20944/preprints202409.0951.v1
APA Style
Vij, P., Hussain, M. S., Satapathy, S. K., Cobos, E., & Tripathi, M. K. (2024). The Emerging Role of Long Noncoding RNAs’ in Sorafenib Resistance within Hepatocellular Carcinoma. Preprints. https://doi.org/10.20944/preprints202409.0951.v1
Chicago/Turabian Style
Vij, P., Everardo Cobos and Manish Kumar Tripathi. 2024 "The Emerging Role of Long Noncoding RNAs’ in Sorafenib Resistance within Hepatocellular Carcinoma" Preprints. https://doi.org/10.20944/preprints202409.0951.v1
Abstract
Hepatocellular carcinoma (HCC) is a liver cancer that originates from hepatocytes. It is a primary health issue and one of the most common malignant tumors. The US FDA approved Sorafenib as the first-line anti-cancer drug for advanced HCC patients. A few patients with advanced HCC may benefit from Sorafenib treatment, but most of the patients eventually develop resistance to Sorafenib, which leads to its poor prognosis. Long-noncoding RNAs (lncRNA) have been found to play a critical role in tumorigenesis and the development of HCC, as well as various cancers. It also plays a vital role in tumor drug resistance, while the mechanisms of LncRNAs in HCC sorafenib resistance have not been characterized yet. In this review article, we summarized the molecular mechanisms, such as the involvement of transporters, receptors, cell death regulation, and other factors impacting sorafenib resistance in HCC.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
