Version 1
: Received: 11 September 2024 / Approved: 12 September 2024 / Online: 13 September 2024 (10:43:26 CEST)
How to cite:
Barna, B.; Caldas, L. A.; Monteiro, J.; Santos, A. L.; Pascon, R. C.; Vallim, M. A.; Ferreira, M. J. P.; Gonçalves, S. S.; Santos, G. Q. D.; Rodrigues, A. M.; Carvalho, J. A. D.; Vasconcellos, S. P. D.; Sartorelli, P. Dereplication of Tetronic Acid Derivatives Produced by Calea pinnatifida (Asteraceae) Endophytes and Their Antimicrobial Properties. Preprints2024, 2024091039. https://doi.org/10.20944/preprints202409.1039.v1
Barna, B.; Caldas, L. A.; Monteiro, J.; Santos, A. L.; Pascon, R. C.; Vallim, M. A.; Ferreira, M. J. P.; Gonçalves, S. S.; Santos, G. Q. D.; Rodrigues, A. M.; Carvalho, J. A. D.; Vasconcellos, S. P. D.; Sartorelli, P. Dereplication of Tetronic Acid Derivatives Produced by Calea pinnatifida (Asteraceae) Endophytes and Their Antimicrobial Properties. Preprints 2024, 2024091039. https://doi.org/10.20944/preprints202409.1039.v1
Barna, B.; Caldas, L. A.; Monteiro, J.; Santos, A. L.; Pascon, R. C.; Vallim, M. A.; Ferreira, M. J. P.; Gonçalves, S. S.; Santos, G. Q. D.; Rodrigues, A. M.; Carvalho, J. A. D.; Vasconcellos, S. P. D.; Sartorelli, P. Dereplication of Tetronic Acid Derivatives Produced by Calea pinnatifida (Asteraceae) Endophytes and Their Antimicrobial Properties. Preprints2024, 2024091039. https://doi.org/10.20944/preprints202409.1039.v1
APA Style
Barna, B., Caldas, L. A., Monteiro, J., Santos, A. L., Pascon, R. C., Vallim, M. A., Ferreira, M. J. P., Gonçalves, S. S., Santos, G. Q. D., Rodrigues, A. M., Carvalho, J. A. D., Vasconcellos, S. P. D., & Sartorelli, P. (2024). Dereplication of Tetronic Acid Derivatives Produced by Calea pinnatifida (Asteraceae) Endophytes and Their Antimicrobial Properties. Preprints. https://doi.org/10.20944/preprints202409.1039.v1
Chicago/Turabian Style
Barna, B., Suzan Pantaroto de Vasconcellos and Patricia Sartorelli. 2024 "Dereplication of Tetronic Acid Derivatives Produced by Calea pinnatifida (Asteraceae) Endophytes and Their Antimicrobial Properties" Preprints. https://doi.org/10.20944/preprints202409.1039.v1
Abstract
Almost fifty years after the introduction of antibiotics as an antimicrobial agent, we are facing an increasing number of multi-resistant microbials. The search for new antimicrobial compounds emerged as a promising alternative to treatments for diseases caused by microorganisms such as fungi and bacteria. Thus, endophytic fungi are gaining recognition for their varied metabolites that may possess antimicrobial properties. In our research, we isolated, from Calea pinnatifida, six endophytic fungi identified as Colletotrichum siamense, Colletotrichum karstii, Hypomontagnella barbarensis, Neopestalotiopsis clavispora, Nigrospora sacchari-officinarum and Annulohypoxylon moriforme. Analyses of microbial secondary metabolites by utilizing UHPLC-HR-ESI-MS/MS in conjunction with molecular networking, allowed the annotation of 9 compounds, 5 of them from GNPS spectral library match, and 4 from prediction-based on the molecular network, and allowed the isolation of two pairs of Acyl-tetronic acid derivatives distereoisomeric identified by NMR spectrum. In this sense, the present study underlines the value of endophytic fungi as a reservoir of potentially new antimicrobial agents.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
