(4aS, 5S, 6aR, 10aR, 10bR)-5-Methoxy-9,9-Dimethyl-4a, 5,6a, 7,10a, 10b-Hexahydro-12H-[1,3]dioxino[4′, 5’:5,6]pyrano[4,3-b][1,2, 3]triazolo[1,5-d][1,4]oxazine

Leticia Lomas Romero; Guillermo E. Negrón Silva; Ricardo Corona Sánchez; Elsie Ramírez Domínguez; Atilano Gutiérrez Carrillo; Alma Sánchez Eleuterio

doi:10.20944/preprints202409.1071.v1

How to cite: Lomas Romero, L.; Negrón Silva, G. E.; Corona Sánchez, R.; Ramírez Domínguez, E.; Gutiérrez Carrillo, A.; Sánchez Eleuterio, A. (4aS, 5S, 6aR, 10aR, 10bR)-5-Methoxy-9,9-Dimethyl-4a, 5,6a, 7,10a, 10b-Hexahydro-12H-[1,3]dioxino[4′, 5’:5,6]pyrano[4,3-b][1,2, 3]triazolo[1,5-d][1,4]oxazine. Preprints 2024, 2024091071. https://doi.org/10.20944/preprints202409.1071.v1 Lomas Romero, L.; Negrón Silva, G. E.; Corona Sánchez, R.; Ramírez Domínguez, E.; Gutiérrez Carrillo, A.; Sánchez Eleuterio, A. (4aS, 5S, 6aR, 10aR, 10bR)-5-Methoxy-9,9-Dimethyl-4a, 5,6a, 7,10a, 10b-Hexahydro-12H-[1,3]dioxino[4′, 5’:5,6]pyrano[4,3-b][1,2, 3]triazolo[1,5-d][1,4]oxazine. Preprints 2024, 2024091071. https://doi.org/10.20944/preprints202409.1071.v1

Abstract

A new tetracyclic morpholine-fused [5,1-c]-triazole, (4aS,5S,6aR,10aR,10bR)-5-methoxy-9,9-dimethyl-4a,5,6a,7,10a,10b-hexahydro-12H-[1,3]dioxino[4',5':5,6]pyrano[4,3-b][1,2,3]triazolo[1,5-d][1,4]oxazine, was synthesized via a five-step sequence starting from methyl α-D-glucopyranoside by using as a key step an intramolecular copper(I) cat-alyzed alkyne-azide cycloaddition (CuAAC). The synthesized compound was fully characterized by 1H and 13C NMR, FT-IR, and HRMS.

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(4aS, 5S, 6aR, 10aR, 10bR)-5-Methoxy-9,9-Dimethyl-4a, 5,6a, 7,10a, 10b-Hexahydro-12H-[1,3]dioxino[4′, 5’:5,6]pyrano[4,3-b][1,2, 3]triazolo[1,5-d][1,4]oxazine

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