Version 1
: Received: 13 September 2024 / Approved: 15 September 2024 / Online: 16 September 2024 (12:29:00 CEST)
How to cite:
Salgado-Hernández, S. V.; Martínez-Retamoza, L.; Ocadiz-Delgado, R.; Pérez-Mora, S.; Cedeño-Arboleda, G.; Gómez-García, M. D. C.; Gariglio, P.; Pérez-Ishiwara, D. G. Dysregulated Expression of Selected miRNAs in Human Papillomavirus-Positive Patients with Benign Prostatic Hyperplasia/Prostatitis and Prostate Cancer. Preprints2024, 2024091179. https://doi.org/10.20944/preprints202409.1179.v1
Salgado-Hernández, S. V.; Martínez-Retamoza, L.; Ocadiz-Delgado, R.; Pérez-Mora, S.; Cedeño-Arboleda, G.; Gómez-García, M. D. C.; Gariglio, P.; Pérez-Ishiwara, D. G. Dysregulated Expression of Selected miRNAs in Human Papillomavirus-Positive Patients with Benign Prostatic Hyperplasia/Prostatitis and Prostate Cancer. Preprints 2024, 2024091179. https://doi.org/10.20944/preprints202409.1179.v1
Salgado-Hernández, S. V.; Martínez-Retamoza, L.; Ocadiz-Delgado, R.; Pérez-Mora, S.; Cedeño-Arboleda, G.; Gómez-García, M. D. C.; Gariglio, P.; Pérez-Ishiwara, D. G. Dysregulated Expression of Selected miRNAs in Human Papillomavirus-Positive Patients with Benign Prostatic Hyperplasia/Prostatitis and Prostate Cancer. Preprints2024, 2024091179. https://doi.org/10.20944/preprints202409.1179.v1
APA Style
Salgado-Hernández, S. V., Martínez-Retamoza, L., Ocadiz-Delgado, R., Pérez-Mora, S., Cedeño-Arboleda, G., Gómez-García, M. D. C., Gariglio, P., & Pérez-Ishiwara, D. G. (2024). Dysregulated Expression of Selected miRNAs in Human Papillomavirus-Positive Patients with Benign Prostatic Hyperplasia/Prostatitis and Prostate Cancer. Preprints. https://doi.org/10.20944/preprints202409.1179.v1
Chicago/Turabian Style
Salgado-Hernández, S. V., Patricio Gariglio and David Guillermo Pérez-Ishiwara. 2024 "Dysregulated Expression of Selected miRNAs in Human Papillomavirus-Positive Patients with Benign Prostatic Hyperplasia/Prostatitis and Prostate Cancer" Preprints. https://doi.org/10.20944/preprints202409.1179.v1
Abstract
Chronic prostatitis has been found to be associated with the genesis of Benign Prostatic Hyper-plasia (BPH) and subsequent development of prostate cancer (PCa). It has been described that human papillomavirus (HPV) tends to infect the prostatic epithelium; however, correlation be-tween HPV infection and prostate pathology remains to be elucidated. Considering that HPV in-fection can affect cellular pathways, we investigated here the putative role of HPV in the expres-sion of selected miRNAs involved in inflammation, proliferation, and oncogenesis in BPH, BPH/prostatitis and PCa clinical samples. Our results demonstrated that 67.2 % of benign lesions and 93.4% of cancer samples were HPV-positive. Interestingly, we found downregulation of miR-34a, miR-143, and miR-145, as well as upregulation of miR-221 in tissue with BPH and BPH/prostatitis. In HPV-positive PCa samples, let-7c, miR-34a, miR-126, miR-221, miR-145, and miR-106a were found to be downregulated, suggesting their involvement in the formation of a pro-oncogenic microenvironment. Consistent with these results, we found that altered expression levels of miR-34a, miR-145, miR-106a, miR-21 and miR-221 showed a correlation with high-risk HPV-positive PCa samples. The differential expression of these miRNAs induced by HPV could be useful for the identification of potential therapeutic biomarkers, opening a new approach for di-agnosis, prognosis, and therapeutic targeting in prostate cancer.
Biology and Life Sciences, Biochemistry and Molecular Biology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
