PreprintCase ReportVersion 1This version is not peer-reviewed
Novel Compound Nonsense Variant in the CYP27B1 Cause an Atypical Form of Vitamin D-Dependent Rickets Type 1A: Case Report in Two Siblings in a Mexican Family
Version 1
: Received: 13 September 2024 / Approved: 16 September 2024 / Online: 16 September 2024 (12:28:07 CEST)
How to cite:
López, J. T.; Tenopala, C. C.; Mosqueda, D. R.; Sánchez, M. Á. F.; Huerta, L. M. G. Novel Compound Nonsense Variant in the CYP27B1 Cause an Atypical Form of Vitamin D-Dependent Rickets Type 1A: Case Report in Two Siblings in a Mexican Family. Preprints2024, 2024091226. https://doi.org/10.20944/preprints202409.1226.v1
López, J. T.; Tenopala, C. C.; Mosqueda, D. R.; Sánchez, M. Á. F.; Huerta, L. M. G. Novel Compound Nonsense Variant in the CYP27B1 Cause an Atypical Form of Vitamin D-Dependent Rickets Type 1A: Case Report in Two Siblings in a Mexican Family. Preprints 2024, 2024091226. https://doi.org/10.20944/preprints202409.1226.v1
López, J. T.; Tenopala, C. C.; Mosqueda, D. R.; Sánchez, M. Á. F.; Huerta, L. M. G. Novel Compound Nonsense Variant in the CYP27B1 Cause an Atypical Form of Vitamin D-Dependent Rickets Type 1A: Case Report in Two Siblings in a Mexican Family. Preprints2024, 2024091226. https://doi.org/10.20944/preprints202409.1226.v1
APA Style
López, J. T., Tenopala, C. C., Mosqueda, D. R., Sánchez, M. Á. F., & Huerta, L. M. G. (2024). Novel Compound Nonsense Variant in the CYP27B1 Cause an Atypical Form of Vitamin D-Dependent Rickets Type 1A: Case Report in Two Siblings in a Mexican Family. Preprints. https://doi.org/10.20944/preprints202409.1226.v1
Chicago/Turabian Style
López, J. T., Miguel Ángel Fonseca Sánchez and Luz María González Huerta. 2024 "Novel Compound Nonsense Variant in the CYP27B1 Cause an Atypical Form of Vitamin D-Dependent Rickets Type 1A: Case Report in Two Siblings in a Mexican Family" Preprints. https://doi.org/10.20944/preprints202409.1226.v1
Abstract
Vitamin D-dependent rickets type 1A (VDDR1A) is a rare autosomal recessive disorder, caused by pathogenic variants in the CYP27B1 gene, typically characterized by growth failure, rickets, leg bowing, fracture, seizures, hyperparathyroidism, hypocalcemia, high alkaline phosphatase, high or normal 25(OH)D3, and low 1,25(OH)2D3. We studied two siblings in a Mexican family with an atypical form of VDDR1A. In addition to the typical features of VDDR1A, the proband showed cafe au lait spots, small teeth and grayish sclera, with hypophosphatemia, normocalcemia and normal 25(OH)D3, the proband´s brother showed grayish sclera. Proband underwent Next Generation Sequencing. Sanger sequencing was performed in the proband, his brother, the parents and 100 healthy controls for validation of detected variant. Both brothers presented a recurrent variant NM_000785.3; c.1319_1325dupCCCACCC and a novel nonsense variant NM_000785.3; c.227G>A in the CYP27B1 gene. Calcitriol treatment had better response in proband´s younger brother. We describe the first Mexican family with an atypical form of VDDR1A associated with novel nonsense variant, the results contribute to the phenotypic spectrum and increases the pool of pathogenic variants in CYP27B1. Data suggesting that nonsense-truncating variants play a significant role in the severity of VDDR1A.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
