Version 1
: Received: 17 September 2024 / Approved: 17 September 2024 / Online: 17 September 2024 (11:39:00 CEST)
How to cite:
Blount, S. L.; Liu, X.; McBride, J. D. The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma. Preprints2024, 2024091316. https://doi.org/10.20944/preprints202409.1316.v1
Blount, S. L.; Liu, X.; McBride, J. D. The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma. Preprints 2024, 2024091316. https://doi.org/10.20944/preprints202409.1316.v1
Blount, S. L.; Liu, X.; McBride, J. D. The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma. Preprints2024, 2024091316. https://doi.org/10.20944/preprints202409.1316.v1
APA Style
Blount, S. L., Liu, X., & McBride, J. D. (2024). The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma. Preprints. https://doi.org/10.20944/preprints202409.1316.v1
Chicago/Turabian Style
Blount, S. L., Xiaochen Liu and Jeffrey Don McBride. 2024 "The Utilization of PRAME in the Diagnosis, Prognosis, and Treatment of Melanoma" Preprints. https://doi.org/10.20944/preprints202409.1316.v1
Abstract
Melanoma, a deadly form of skin cancer, has seen improved survival rates due to advances in diagnosis and treatment, yet the need for further improvement remains critical. Tumor-associated antigens, such as PRAME (Preferentially Expressed Antigen in Melanoma), offer promising avenues for enhanced diagnostic precision, prognostic assessment, and targeted immunotherapy. PRAME, a cancer-testis antigen, is selectively expressed in various cancers, including melanoma, and plays a key role in promoting tumorigenesis through inhibition of retinoic acid signaling, epithelial-to-mesenchymal transition, and immune evasion. This review explores the diagnostic utility of PRAME in distinguishing melanoma from benign nevi, its prognostic value in aggressive melanoma subtypes, and its potential as a therapeutic target in cancer vaccines and adoptive T-cell therapies. While PRAME-targeted therapies face challenges such as tumor heterogeneity and immune suppression, ongoing research aims to overcome these barriers, offering hope for more effective melanoma treatments.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
